Platelet-Rich Plasma and Cell Therapy

July 2021 in “ Dermatologic clinics ”

Aditya K. Gupta, Helen J. Renaud, Jeffrey A. Rapaport

platelet-rich plasma cell-based therapies regenerative medicine hair loss PRP

TLDR PRP and cell therapies may help with hair loss, but more research is needed.

Current medicinal therapies for hair loss often face issues like variability, ineffectiveness, noncompliance, and adverse effects. The psychological impact of hair loss has led to research into regenerative medicine, including platelet-rich plasma (PRP) and cell-based therapies, as potential alternatives. These therapies show promising results, but more robust trials are necessary to confirm their efficacy. Additionally, standardization in treatment preparation, dosage, and regimen is required.

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Platelet-Rich Plasma (PRP) could potentially help regrow hair in people with Alopecia Areata, but more research is needed to confirm its effectiveness.

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23 citations , October 2020 in “Journal of Cosmetic Dermatology”

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13 citations , September 2020 in “International Journal of Molecular Sciences”

PRP therapy and minoxidil combo works best for male hair loss.

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3 citations , August 2020 in “PubMed”

Platelet-rich plasma (PRP) is effective in treating various skin conditions and improving hair density, thickness, and patient satisfaction, with lower relapse rates for Alopecia Areata.

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research A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women

22 citations , June 2020 in “Dermatologic Surgery”

Both Platelet-Rich Plasma and Minoxidil foam increase hair count in women with hair loss, but Minoxidil is more effective. However, women were more satisfied with Platelet-Rich Plasma treatment.

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research Platelet-Rich Plasma Injections in the Treatment of Male Androgenetic Alopecia: A Randomized Placebo-Controlled Crossover Study

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PRP injections improve hair density in male hair loss.

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QR678 treatments were more effective and comfortable for male hair loss than PRP treatments.

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research Dermoscopic Pre- And Post-Treatment Evaluation In Patients With Androgenetic Alopecia On Platelet-Rich Plasma—A Prospective Study

5 citations , October 2019 in “Journal of Cosmetic Dermatology”

PRP treatment improves hair count, density, and reduces hair loss in AGA patients.

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39 citations , October 2019 in “Dermatologic Surgery”

PRP therapy increases hair density for androgenetic alopecia.

research Efficacy of Platelet-Rich Plasma for Treating Androgenic Alopecia of Varying Grades

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Platelet-rich plasma injections significantly improve hair density and thickness in both male and female pattern hair loss, especially in early stages.

research Efficacy of Platelet-Rich Plasma in Androgenetic Alopecia Patients

14 citations , August 2019 in “Journal of Cosmetic Dermatology”

PRP therapy safely improves hair growth in people with hair loss.

research Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels

57 citations , March 2019 in “Journal of The American Academy of Dermatology”

Platelet-rich plasma treatment can significantly increase hair count and density in men with pattern baldness, and these improvements can last up to 3 months.

research Platelet-Rich Plasma on Female Androgenetic Alopecia: Tested on 10 Patients

25 citations , February 2019 in “Journal of Cosmetic Dermatology”

PRP injections increase hair density and diameter in female androgenetic alopecia patients.

research The Efficacy of Platelet-Rich Plasma in Hair Restoration and Facial Aesthetics: A Systematic Review and Meta-Analysis

31 citations , January 2019 in “Journal of Cutaneous Medicine and Surgery”

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research Injectable Platelet-Rich Fibrin with Stem Cells for the Treatment of Alopecia: A Report of Three Patients

18 citations , January 2019 in “International journal of trichology”

The treatment improved hair growth in three patients with alopecia.

research Morphological Substantiation of Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia

3 citations , December 2018 in “International Journal of Biomedicine”

Platelet rich plasma therapy significantly improves hair growth and increases the number of hair follicles in men with androgenetic alopecia.

research Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis

54 citations , December 2018 in “Journal of The European Academy of Dermatology and Venereology”

Low level laser therapy works best for hair loss, followed by PRP, finasteride, and minoxidil.

research Review of Human Hair Follicle Biology: Dynamics of Niches and Stem Cell Regulation for Possible Therapeutic Hair Stimulation for Plastic Surgeons

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research Synergistic Effect of Platelet-Rich Plasma Injections and Scalp Lifting in Androgenetic Alopecia

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PRP injections and scalp lifting together improve hair thickness and growth in hair loss patients.

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research Introducing Platelet-Rich Stroma: Platelet-Rich Plasma and Stromal Vascular Fraction Combined for the Treatment of Androgenetic Alopecia

40 citations , July 2018 in “Aesthetic Surgery Journal”

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research Platelet-Rich Plasma with Microneedling in Androgenetic Alopecia Along with Dermoscopic Pre- and Post-Treatment Evaluation

36 citations , June 2018 in “Journal of Cosmetic Dermatology”

PRP with microneedling effectively treats hair loss, and dermoscopy helps evaluate results.

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

87 citations , June 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

research Cellular Therapy with Human Autologous Adipose-Derived Adult Cells of Stromal Vascular Fraction for Alopecia Areata

45 citations , May 2018 in “Stem Cell Research & Therapy”

Using patients' own fat-derived cells to treat alopecia areata significantly improved hair growth and was safe.

research Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

39 citations , March 2018 in “Journal of Dermatological Treatment”

Stem cell therapy may help treat tough hair loss cases.

research The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study

52 citations , February 2018 in “Journal of Cosmetic Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

research Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma for Treating Androgenic Alopecia

24 citations , February 2018 in “Aesthetic Plastic Surgery”

All types of Platelet-Rich Plasma (PRP) can treat hair loss, but homologous PRP works best due to its higher platelet count and growth factors from multiple donors.

research Platelet-Rich Plasma by Single Spin Process in Male Pattern Androgenetic Alopecia: Is It an Effective Treatment?

27 citations , November 2017 in “Indian Dermatology Online Journal”

research Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells

55 citations , September 2017 in “Current stem cell research & therapy”

Using fat-derived stem cells for hair loss treatment is safe and effective, improving hair growth and patient satisfaction.

research Hair Follicle Growth by Stromal Vascular Fraction-Enhanced Adipose Transplantation in Baldness

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research A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

348 citations , July 2017 in “Skin appendage disorders”

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Stem cells from hair follicles can safely treat hair loss.

research Platelet-Rich Plasma in Combination With 5% Minoxidil Topical Solution and 1 mg Oral Finasteride for the Treatment of Androgenetic Alopecia: A Randomized Placebo-Controlled, Double-Blind, Half-Head Study

19 citations , May 2017 in “Dermatologic Surgery”

Combining platelet-rich plasma with 5% minoxidil solution improves hair regrowth in androgenetic alopecia patients.

research The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study

70 citations , May 2017 in “Dermatologic Surgery”

Treatment with plasma rich in growth factors improved hair density and thickness for hair loss patients.

research A Split Head Study of Efficacy of Placebo Versus Platelet-Rich Plasma Injections in the Treatment of Androgenic Alopecia

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Platelet-rich plasma injections can effectively treat male pattern hair loss, improving hair density and quality with high patient satisfaction.

research Androgenetic Alopecia: A Review

153 citations , March 2017 in “Endocrine”

Male pattern baldness involves genetics, hormones, and needs better treatments.

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations , February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research A Critical Assessment of the Evidence for Low-Level Laser Therapy in the Treatment of Hair Loss

32 citations , February 2017 in “Dermatologic Surgery”

The evidence for using Low-Level Laser Therapy for hair loss is limited and more thorough research is needed.

research Meta-Analysis of Efficacy of Platelet-Rich Plasma Therapy for Androgenetic Alopecia

57 citations , January 2017 in “Journal of Dermatological Treatment”

PRP therapy may effectively treat hair loss, but more research needed.

research Platelet-Rich Plasma Versus Minoxidil 5% in Treatment of Alopecia Areata: A Trichoscopic Evaluation

62 citations , January 2017 in “Dermatologic Therapy”

PRP more effective than minoxidil 5% for treating alopecia areata.

research A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia

60 citations , December 2016 in “Dermatologic Surgery”

PRP treatment may stimulate hair growth by promoting blood vessel formation, increasing growth factors, and preventing cell death.

research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

87 citations , November 2016 in “Dermatologic Surgery”

PRP shows potential for treating female hair loss, but more research needed.

research Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic (Male-Patterned) Alopecia: A Pilot Randomized Controlled Trial

61 citations , October 2016 in “Journal of Cosmetic and Laser Therapy”

Platelet-rich plasma (PRP) was found not effective in treating male-patterned hair loss.

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations , April 2016 in “Dermatologic Surgery”

PRP treatment helps hair growth and density in androgenetic alopecia patients.

research Platelet-Rich Plasma as a Novel Treatment for Lichen Planopillaris

29 citations , March 2016 in “Dermatologic therapy”

Platelet-rich plasma may successfully treat lichen planopillaris, as shown by one patient's symptom regression.

research Platelet-Rich Plasma Combined with Intralesional Triamcinolone Acetonide for the Treatment of Alopecia Areata: A Case Report

15 citations , January 2016 in “Journal of Dermatology and Dermatologic Surgery”

Mixing platelet-rich plasma with triamcinolone acetonide can potentially improve hair regrowth in alopecia areata patients.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

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30 citations , September 2015 in “JAAD case reports”

Platelet-rich plasma (PRP) injections successfully treated a woman's steroid-resistant hair loss, causing hair to regrow within a month.

research Efficacy of Platelet-Rich Plasma in Treatment of Androgenic Alopecia

74 citations , July 2015 in “Asian Journal of Transfusion Science”

Platelet-rich plasma (PRP) injections can effectively increase hair density and thickness in people with androgenic alopecia, without major side effects.

research Autologous Platelet-Rich Plasma as a Treatment for Male Androgenetic Alopecia: Study of 14 Cases

4 citations , June 2015 in “Journal of clinical & experimental dermatology research”

PRP injections may slightly improve hair density and count for male hair loss, but more research is needed.

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

83 citations , June 2015 in “International Journal of Dermatology”

ADSC-CM treatment improved hair density and thickness in women with hair loss, safely and effectively.

research Effects of Dihydrotestosterone on Rat Dermal Papilla Cells In Vitro

19 citations , June 2015 in “European Journal of Pharmacology”

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

research Hair Regrowth in Alopecia Areata Patients Following Stem Cell Educator Therapy

55 citations , April 2015 in “BMC medicine”

Stem Cell Educator therapy helps regrow hair and improve life quality in alopecia areata patients.

research Drug Discovery for Alopecia: Gone Today, Hair Tomorrow

70 citations , February 2015 in “Expert Opinion on Drug Discovery”

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research Role of Platelet-Rich Plasma in Chronic Alopecia Areata: Our Centre Experience

61 citations , January 2015 in “Indian Journal of Plastic Surgery”

Platelet-rich plasma treatment could potentially be an effective way to treat chronic alopecia areata with minimal side effects.

research Intralesional Platelet-Rich Plasma vs. Intralesional Triamcinolone in the Treatment of Alopecia Areata: A Comparative Study

15 citations , January 2015 in “International journal of medical research and health sciences”

Platelet rich plasma is as effective as triamcinolone for treating alopecia areata.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , October 2014 in “Journal of Cutaneous and Aesthetic Surgery”

PRP injections increase hair density and satisfaction in androgenetic alopecia patients.

research Platelet-Rich Plasma for Androgenetic Alopecia

107 citations , September 2014 in “Dermatologic Surgery”

PRP injections improve hair thickness for baldness.

research A Case Series of 46 Patients With Lichen Planopilaris: Demographics, Clinical Evaluation, and Treatment Experience

47 citations , July 2014 in “Journal of Dermatological Treatment”

Most treatments for lichen planopilaris were found to be generally unsatisfactory.

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88 citations , January 2014 in “Journal of The European Academy of Dermatology and Venereology”

Injecting CD34+ cell-containing platelet-rich plasma into the scalp can improve hair count and thickness in people with pattern hair loss.

research Limited Effectiveness of Platelet-Rich Plasma Treatment on Chronic Severe Alopecia Areata

15 citations , January 2014 in “Hair therapy & transplantation”

Platelet-Rich Plasma treatment has limited and temporary effects on severe Alopecia Areata and does not prevent relapses.

research Platelet-Rich Plasma in Dermatology: Boon or Bane?

119 citations , January 2014 in “Indian Journal of Dermatology, Venereology and Leprology”

Platelet-rich plasma might help with hair growth and skin conditions, but more research is needed to prove its effectiveness and safety.

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research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations , January 2014 in “BioMed Research International”

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

research Platelet-Rich Plasma in Androgenic Alopecia: Myth or Effective Tool

115 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

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research Stem Cell Dynamics in the Hair Follicle Niche

135 citations , January 2014 in “Seminars in Cell & Developmental Biology”

Stem cells in the hair follicle are regulated by their surrounding environment, which is important for hair growth.

research A Randomized, Double-Blind, Placebo- and Active-Controlled, Half-Head Study to Evaluate the Effects of Platelet-Rich Plasma on Alopecia Areata

205 citations , August 2013 in “British Journal of Dermatology”

Platelet-rich plasma treatment significantly increased hair regrowth and decreased discomfort in alopecia patients, making it a potentially better and safer treatment option.

research Health Status, Coping Strategies, and Alexithymia in Subjects with Androgenetic Alopecia

40 citations , February 2013 in “American Journal of Clinical Dermatology”

People with hair loss feel more depressed and anxious, especially women, and need help managing emotions and beliefs about their condition.

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

170 citations , January 2013 in “Journal of Investigative Dermatology”

Wnt ligands are crucial for hair growth and repair.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , July 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

research Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

95 citations , May 2012 in “British Journal of Dermatology”

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations , January 2012 in “Cell stem cell”

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

research Enhanced Effect of Platelet-Rich Plasma Containing a New Carrier on Hair Growth

166 citations , December 2011 in “Dermatologic Surgery”

Platelet-rich plasma with a new carrier significantly increases hair thickness without serious side effects.

research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

176 citations , April 2011 in “Science”

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research Expression Patterns of Glial Cell Line-Derived Neurotrophic Factor, Neurturin, Their Cognate Receptors GFRα-1, GFRα-2, and Common Signal Transduction Element c-Ret in Human Skin Hair Follicles

18 citations , February 2008 in “Journal of The American Academy of Dermatology”

Certain proteins and their receptors are more active during the growth phase of human hair and could be targeted to treat hair disorders.

1 / 1 results

research Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma for Treating Androgenic Alopecia

24 citations , February 2018 in “Aesthetic Plastic Surgery”

All types of Platelet-Rich Plasma (PRP) can treat hair loss, but homologous PRP works best due to its higher platelet count and growth factors from multiple donors.