Platelet-Rich Plasma in Combination With 5% Minoxidil Topical Solution and 1 mg Oral Finasteride for the Treatment of Androgenetic Alopecia: A Randomized Placebo-Controlled, Double-Blind, Half-Head Study

May 2017 in “ Dermatologic Surgery ”

Rubina Alves, Ramon Grimalt

platelet-rich plasma 5% minoxidil topical solution 1 mg oral finasteride androgenetic alopecia hair count hair density anagen telogen anagen/telogen ratio DP cells angiogenesis hair regrowth PRP minoxidil finasteride AGA

TLDR Combining platelet-rich plasma with 5% minoxidil solution improves hair regrowth in androgenetic alopecia patients.

This study examined the effectiveness of combining platelet-rich plasma (PRP) with 5% minoxidil topical solution and 1 mg oral finasteride for the treatment of androgenetic alopecia (AGA). The study was a randomized, placebo-controlled, double-blind, half-head study with 24 participants. The results showed that the administration of PRP led to a statistically significant increase in mean hair count and mean hair density versus baseline values at 3 months and 6 months after the first treatment. The combination of PRP and minoxidil 5% solution showed superiority in mean hair count, hair density, anagen and telogen percentages, and mean anagen/telogen ratio in comparison with the association of PRP and finasteride 1 mg. The study suggests that the combination of 5% minoxidil topical solution with pure PRP might have a cumulative effect in DP cells and promote greater angiogenesis and improvement in hair regrowth of AGA patients.

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Research cited in this study

4 / 4 results

Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations, April 2016 in “Dermatologic Surgery”

PRP treatment helps hair growth and density in androgenetic alopecia patients.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations, March 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations, October 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations, March 1998 in “British Journal of Dermatology”

Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

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