A Study to Compare the Efficacy and Safety of Platelet Rich Plasma and Topical Minoxidil Fortified with Finasteride in the Treatment of Androgenic Alopecia in Male Patients

June 2022 in “ IP Indian journal of clinical and experimental dermatology ”

Karaninder S Mehta, Hitender Sharma, Pushpinder S Chauhan, Vinay Mahajan, Monika Chandel, Yograj Verma, Sheenam Hooda, Pushkin Kachroo

platelet-rich plasma topical minoxidil finasteride androgenic alopecia intradermal therapy PRP Rogaine Propecia

From the encyclopedia

Platelet-Rich Plasma →

growth factors taken from your blood and injected into your scalp to stimulate hair

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Studysummary This study found that both intradermal platelet-rich plasma and topical minoxidil with finasteride resulted in similar hair growth improvement in patients with androgenetic alopecia over 12 months. Our plain-language summary of this paper — not a Tressless recommendation.

This study compared the efficacy and safety of intradermal platelet-rich plasma (PRP) therapy and topical minoxidil (5%) fortified with finasteride (0.1%) in treating androgenetic alopecia in 60 male patients over 12 months. Patients were divided into two groups of 30 each. Results showed that in the PRP group, 22 patients (73.3%) experienced 1-25% hair growth improvement, and 8 patients (26.7%) had 26-50% improvement. Similarly, in the minoxidil-fortified group, 21 patients (70%) saw 1-25% improvement, and 8 patients (26.7%) had 26-50% improvement. Both treatments demonstrated comparable efficacy in promoting hair growth.

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Research cited in this study

8 / 8 results

research Comparison of Efficacy of Platelet-Rich Plasma Therapy With or Without Topical 5% Minoxidil in Male-Type Baldness: A Randomized, Double-Blind Placebo Control Trial

26 citations , December 2019 in “Indian Journal of Dermatology, Venereology and Leprology”

This study found that platelet-rich plasma combined with topical minoxidil was more effective in increasing hair density for male-type baldness than either treatment alone.

research A Study to Compare the Efficacy of Platelet-Rich Plasma and Minoxidil Therapy for the Treatment of Androgenetic Alopecia

18 citations , January 2019 in “International Journal of Trichology”

This study found that PRP therapy resulted in better hair growth and patient satisfaction than minoxidil therapy in men with androgenetic alopecia over six months, and patients with higher platelet counts in PRP experienced greater improvement.

research Comparing the Therapeutic Efficacy of Topical Minoxidil and Finasteride with Topical Minoxidil and Oral Finasteride in Androgenetic Alopecia: A Randomized Trial

4 citations , July 2018 in “International Journal of Research in Dermatology”

This study found that among patients with stage III and IV androgenic alopecia, 83% of those using topical 5% minoxidil with topical 0.1% finasteride showed improved hair density, suggesting it may reduce the need for long-term oral finasteride.

research Androgenetic Alopecia: An Evidence-Based Treatment Update

151 citations , May 2014 in “American Journal of Clinical Dermatology”

This review concluded that oral finasteride for men and topical minoxidil for both genders have the most evidence supporting their effectiveness and safety for treating androgenetic alopecia.

research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations , January 2014 in “BioMed Research International”

This study reported that AA-PRP injections significantly increased hair count and density in individuals with pattern hair loss compared to baseline, demonstrating their potential for enhancing hair growth.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , March 2012 in “Dermatologic Surgery”

This study found that autologous platelet-rich plasma increased hair growth potential by enhancing dermal papilla cell proliferation and stimulating key signaling pathways in both cell cultures and mice models.

research Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia

152 citations , October 2010 in “Archives of Dermatology”

This study found that daily oral finasteride may increase hair count and improve hair appearance assessments in men with androgenetic alopecia, but it also appears to raise the risk of sexual dysfunction.

research Burden of Hair Loss: Stress and the Underestimated Psychosocial Impact of Telogen Effluvium and Androgenetic Alopecia

162 citations , August 2004 in “Journal of Investigative Dermatology”

This study suggests that stress negatively affects hair growth by inducing inflammation and early hair cycle transitions in mice, which might inform strategies for managing stress-related hair loss in humans.