Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

September 2020 in “ International Journal of Molecular Sciences ”

Elena G. Pakhomova, I. O. Smirnova

PRP therapy minoxidil androgenetic alopecia immunohistochemical study cell proliferation hair follicle cells proliferative activity pathological signaling pathways PRP Rogaine AGA

TLDR PRP therapy and minoxidil combo works best for male hair loss.

The study compared the effectiveness of PRP therapy, minoxidil, and their combination in treating men with androgenetic alopecia (AGA). The results showed that PRP therapy was more effective than minoxidil therapy, and the combination therapy was even more effective than either therapy alone. Immunohistochemical study showed positive changes in markers of proliferative activity of hair follicle cells after PRP therapy. The study suggests that PRP therapy is a cost-effective and feasible alternative treatment for hair loss. However, further research is needed to explore its potential effects on specific proteins that trigger pathological signaling pathways.

View this study on mdpi.com →

Discuss this study in the Community →

Cited in this study

21 / 21 results

research Platelet-Rich Plasma as a Therapy for Androgenic Alopecia: A Systematic Review and Meta-Analysis

15 citations , February 2022 in “Journal of Dermatological Treatment”

PRP treatment increases hair density and thickness in androgenetic alopecia by 79%.

research A Study to Compare the Efficacy of Platelet-Rich Plasma and Minoxidil Therapy for the Treatment of Androgenetic Alopecia

18 citations , March 2019 in “International Journal of Trichology”

research Morphological Substantiation of Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia

3 citations , December 2018 in “International Journal of Biomedicine”

Platelet rich plasma therapy significantly improves hair growth and increases the number of hair follicles in men with androgenetic alopecia.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

145 citations , January 2018 in “Journal of The European Academy of Dermatology and Venereology”

Use minoxidil for hair loss treatment; assess results after 6 months.

research Platelet-Rich Plasma in Combination With 5% Minoxidil Topical Solution and 1 mg Oral Finasteride for the Treatment of Androgenetic Alopecia: A Randomized Placebo-Controlled, Double-Blind, Half-Head Study

19 citations , May 2017 in “Dermatologic Surgery”

Combining platelet-rich plasma with 5% minoxidil solution improves hair regrowth in androgenetic alopecia patients.

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations , February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research A Comparative Study of Microneedling with Platelet-Rich Plasma Plus Topical Minoxidil (5%) and Topical Minoxidil (5%) Alone in Androgenetic Alopecia

48 citations , January 2017 in “International Journal of Trichology”

Microneedling with platelet-rich plasma and minoxidil improves hair growth more than just minoxidil in men with hair loss.

research Management of Androgenetic Alopecia: A Comparative Clinical Study Between Plasma Rich in Growth Factors and Topical Minoxidil

8 citations , January 2016 in “European Journal of Plastic Surgery”

PRGF treatment is safer and more effective for hair loss than topical minoxidil.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , October 2014 in “Journal of Cutaneous and Aesthetic Surgery”

PRP injections increase hair density and satisfaction in androgenetic alopecia patients.

research Platelet-Rich Fibrin Matrix for Androgenetic Alopecia

25 citations , April 2014 in “Facial Plastic Surgery”

PRFM may help treat hair loss, especially in mild cases.

research The Effect of CD34+ Cell-Containing Autologous Platelet-Rich Plasma Injection on Pattern Hair Loss: A Preliminary Study

88 citations , January 2014 in “Journal of The European Academy of Dermatology and Venereology”

Injecting CD34+ cell-containing platelet-rich plasma into the scalp can improve hair count and thickness in people with pattern hair loss.

research Platelet-Rich Plasma in Androgenic Alopecia: Myth or Effective Tool

115 citations , January 2014 in “Journal of Cutaneous and Aesthetic Surgery”

Platelet-rich plasma (PRP) is a cheap and easy treatment for hair loss, but not suitable for everyone. It also helps in healing ulcers, rejuvenating skin, and improving hair transplants.

research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations , January 2014 in “BioMed Research International”

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

research Platelet-Rich Plasma Injection Is Effective and Safe for the Treatment of Alopecia

45 citations , March 2013 in “European Journal of Plastic Surgery”

Injecting platelet-rich plasma is a safe and effective way to treat hair loss.

research Letter: Platelet-Rich Plasma for Treating Male Pattern Baldness

36 citations , December 2012 in “Dermatologic Surgery”

Injecting platelet-rich plasma (PRP) can increase hair growth rate and density in male pattern baldness.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , July 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

research Hair Growth and Rejuvenation: An Overview

81 citations , June 2010 in “Journal of Dermatological Treatment”

The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.

research Pitx2, A β-Catenin-Regulated Transcription Factor, Regulates The Differentiation Of Outer Root Sheath Cells Cultured In Vitro

51 citations , April 2009 in “Journal of dermatological science”

Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations , November 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Sulfation of minoxidil by human platelet sulfotransferase

39 citations , November 1987 in “Clinica Chimica Acta”

Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

10 / 10 results

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations , November 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research Topical Tofacitinib for the Treatment of Alopecia Areata Affecting Facial Hair

7 citations , June 2021 in “British Journal of Dermatology”

Topical tofacitinib may effectively and safely regrow facial hair in some people with alopecia areata.

research Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis

1 citations , June 2021 in “Journal of Cosmetic Dermatology”

Using minoxidil and tofacitinib together can effectively treat severe hair loss.

research Platelet-Rich Plasma for Hair Loss

12 citations , January 2021 in “Springer eBooks”

research Comparative Evaluation of the Clinical Efficacy of PRP Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

13 citations , September 2020 in “International Journal of Molecular Sciences”

PRP therapy and minoxidil combo works best for male hair loss.

research Platelet-Rich Plasma for the Management of Hair Loss: Better Alone or in Combination?

12 citations , June 2018 in “Journal of Cosmetic Dermatology”

PRP is effective for hair loss and might work better with other treatments, but more research is needed.

research An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata

12 citations , January 2018 in “Journal of Investigative Dermatology Symposium Proceedings”

Platelet-rich plasma and microneedling could potentially help hair growth in people with alopecia areata, but more research is needed.

research Advanced Approaches in Alopecia

4 citations , June 2017 in “Pharmaceutical and Biological Evaluations”

New methods for treating hair loss are being developed.

research Is Platelet Rich Plasma Injection an Effective Treatment for Hair Loss in Androgenic Alopecia and Alopecia Areata

January 2017

research Disorders of Hair

July 2013 in “DeckerMed Medicine”

The document's conclusion cannot be provided because the document is not readable or understandable.