Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

February 2017 in “ International Journal of Molecular Sciences ”

Pietro Gentile, John P. Cole, Megan A Cole, Simone Garcovich, Alessandra Bielli, Maria Giovanna Scioli, Augusto Orlandi, Chiara Insalaco, Valerio Cervelli

platelet-rich plasma PRP androgenetic alopecia AGA autologous PRP A-PRP calcium-activated PRP AA-PRP Regen device Arthrex device Arthrex Angel System male pattern hair loss MPHL hair density follicular unit density growth factors cytokines Regen Arthrex

TLDR PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

The 2017 study assessed the efficacy of platelet-rich plasma (PRP) in treating androgenetic alopecia (AGA) using different protocols and collection systems. The first protocol involved 18 participants who received non-activated autologous PRP (A-PRP) on one half of their head and a placebo on the other half. Results showed significant improvement in hair count and density in the A-PRP treated area compared to the placebo. The second protocol involved 6 participants treated with calcium-activated PRP (AA-PRP) using two different collection devices, with the Regen device showing better hair density outcomes than the Arthrex device. A separate analysis of 18 male patients with mild to moderate male pattern hair loss (MPHL) treated with AA-PRP prepared with the Arthrex Angel System showed significant increases in hair density and follicular unit density. The study concluded that A-PRP treatment is effective in improving hair growth and density, and that different PRP collection devices can affect the outcomes of AA-PRP treatment, with the Arthrex system potentially being more effective due to higher levels of growth factors.

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