The Insulin-Like Growth Factor 1 Receptor Is Expressed by Epithelial Cells with Proliferative Potential in Human Epidermis and Skin Appendages: Correlation of Increased Expression with Epidermal Hyperplasia

    March 1996 in “ Journal of Investigative Dermatology ”
    Emmilia Hodak, Alice B. Gottlieb, Michele Anzilotti, James G. Krueger
    Studysummary Increased IGF-1R expression is linked to thicker skin growth.
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    The study investigated the expression of the Insulin-like Growth Factor 1 Receptor (IGF-1R) in human epidermis and skin appendages, focusing on its presence in epithelial cells with proliferative potential. It found that IGF-1R was expressed in these cells and that its increased expression correlated with epidermal hyperplasia, a condition characterized by the thickening of the epidermis. This suggested that IGF-1R played a role in skin cell proliferation and could be linked to conditions involving abnormal skin growth.
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