Pitx2, A β-Catenin-Regulated Transcription Factor, Regulates The Differentiation Of Outer Root Sheath Cells Cultured In Vitro

February 2009 in “ Journal of dermatological science ”

Kyung-Ah Sohn, Ge Shi, Sunhyae Jang, Dae Eun Choi, Young Lee, Tae‐Jin Yoon, Hwayong Park, Chul Ju Hwang, Hyoung Joo Kim, Young‐Joon Seo, Jeung‐Hoon Lee, Jang-Kyu Park, Chang Deok Kim

β-catenin outer root sheath cells keratin 16 keratin 17 Pitx2 follicular differentiation anagen phase ORS cells hair growth phase

Studysummary In this study, β-catenin overexpression in human hair outer root sheath cells increased the expression of Pitx2, which activated the follicular differentiation pathway, suggesting Pitx2's potential role as a modulator in hair growth control.

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