Interferon Beta Secreted from Human Hair Dermal Papilla Cells Inhibits the Growth of Outer Root Sheath Cells Cultured in Vitro
January 2002
in “
Biochemical and biophysical research communications
”
interferon β outer root sheath cells dermal papilla cells hair follicles differential display reverse transcription–polymerase chain reaction DD RT–PCR Northern blot analysis interferon-inducible gene 6–16 DP-conditioned medium negative regulator of hair growth interferon beta ORS cells DP cells hair growth suppression
Studysummary This study observed that interferon β secreted by dermal papilla cells may negatively regulate the growth of outer root sheath cells in hair follicles.
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The study investigated the molecular interactions between epithelial and mesenchymal cells in hair follicles by culturing outer root sheath (ORS) cells with dermal papilla (DP)-conditioned medium. Using differential display reverse transcription–polymerase chain reaction (DD RT–PCR) and Northern blot analysis, researchers identified that the interferon-inducible gene 6–16 was regulated in ORS cells exposed to DP-conditioned medium. They found that interferon β, secreted by DP cells, was a key factor in this regulation. The presence of interferon β or DP-conditioned medium suppressed the growth of ORS cells in vitro, indicating that interferon β acts as a negative regulator of hair growth.
