Interferon Beta Secreted from Human Hair Dermal Papilla Cells Inhibits the Growth of Outer Root Sheath Cells Cultured in Vitro
January 2002
in “
Biochemical and biophysical research communications
”
interferon β outer root sheath cells dermal papilla cells hair follicles differential display reverse transcription–polymerase chain reaction DD RT–PCR Northern blot analysis interferon-inducible gene 6–16 DP-conditioned medium negative regulator of hair growth interferon beta ORS cells DP cells hair growth suppression
TLDR Interferon β from hair cells stops the growth of other hair cells.
The study investigated the molecular interactions between epithelial and mesenchymal cells in hair follicles by culturing outer root sheath (ORS) cells with dermal papilla (DP)-conditioned medium. Using differential display reverse transcription–polymerase chain reaction (DD RT–PCR) and Northern blot analysis, researchers identified that the interferon-inducible gene 6–16 is regulated in ORS cells by DP-conditioned medium. They found that interferon β, secreted by DP cells, is a key factor in this regulation. The presence of interferon β or DP-conditioned medium suppressed the growth of ORS cells in vitro, indicating that interferon β acts as a negative regulator of hair growth.
