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Effect of DNA Aptamer Through Blocking of Negative Regulation of Wnt/Beta-Catenin Signaling in Human Hair Follicle Dermal Papilla Cells

research Effect of DNA aptamer through blocking of negative regulation of Wnt/β‐catenin signaling in human hair follicle dermal papilla cells

May 2023 in “Skin research and technology”

This study found that WD-aptamer increased β-catenin expression and promoted human hair follicle dermal papilla cell proliferation by interfering with the CXXC5-Dvl1 interaction in the Wnt signaling pathway.

research Interferon β Secreted from Human Hair Dermal Papilla Cells Inhibits the Growth of Outer Root Sheath Cells Cultured in Vitro

13 citations , January 2002 in “Biochemical and biophysical research communications”

This study observed that interferon β secreted by dermal papilla cells may negatively regulate the growth of outer root sheath cells in hair follicles.

The Negative Regulator CXXC5: Making WNT Look a Little Less Disheveled

research The Negative Regulator CXXC5: Making WNT Look a Little Less Dishevelled

8 citations , September 2017 in “Journal of Investigative Dermatology”

This study found that inhibiting the interaction between CXXC5 and Dishevelled could stimulate hair regrowth in mouse models by enhancing WNT/β-catenin signaling, suggesting a potential therapeutic strategy for hair loss involving compounds that block this interaction, such as interfering short peptides.

research MAD2B acts as a negative regulatory partner of TCF4 on proliferation in human dermal papilla cells

8 citations , September 2017 in “Scientific Reports”

This study found that the mitotic arrest deficient protein MAD2B negatively affects TCF4-induced growth and proliferation of dermal papilla cells, which are vital for hair follicle development.

research Commentary on: Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis

5 citations , October 2013 in “Experimental Dermatology”

This study observed that putrescine and HR form a negative feedback mechanism affecting hair cycling, indicating a significant connection between HR, polyamines, and hair growth regulation.

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community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

4 upvotes 1 year ago

Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.

community Are carbohydrates needed for hair growth

26 upvotes 2 years ago

A 47-year-old male experienced significant hair loss after losing 37 kg in 6 months on a low-carb diet and started taking biotin, zinc, iron, selenium, and spectral dcn-n. Replies suggest that while carbs are not directly needed for hair growth, they help regulate hormones and nutrient absorption, and rapid weight loss can also contribute to hair loss.

community Why are people so negative regarding Clascoterone (Breezula)?

20 upvotes 4 months ago

Clascoterone (Breezula) shows promising hair growth results, but skepticism remains due to past disappointments with new treatments. It may be a good alternative for those who can't tolerate finasteride or dutasteride, and can potentially be combined with them and minoxidil for better results.

community Intermittent fasting reduces hair growth?!? :(

35 upvotes 1 year ago

Intermittent fasting may inhibit hair growth by triggering a stress response that affects hair-follicle stem cells. Some users believe genetics and DHT play a larger role in hair loss, and treatments like Minoxidil and Finasteride are mentioned as ineffective for some.

community PP405: The Ultimate Hair Loss Drug for Complete Hair Growth

211 upvotes 1 year ago

PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hair follicle stem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.

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Learn

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learn Epidermal Growth Factor

learn Procyanidin

bioflavonoid found in plants with antioxidant and hair stimulating properties

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Overview

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Follistatin

What is follistatin, and how does it influence hair follicle growth and regeneration? Follistatin blocks activin and related growth-inhibiting proteins, which in laboratory and animal work is described as keeping hair follicles in their growth phase; the only verifiable human evidence is a single small 2011 phase 1 injection trial, so follistatin remains experimental and is not an approved hair-loss treatment.

learn SCUBE3

How does SCUBE3 work on hair follicles compared to treatments like minoxidil or finasteride? Laboratory research in mice reports that SCUBE3, a protein released by dermal papilla cells, signals dormant follicles to grow through the TGF-β pathway downstream of Hedgehog; minoxidil and finasteride instead work on blood flow to the follicle and on DHT, and unlike SCUBE3 they have decades of human trial data behind them. SCUBE3 has not been tested in human clinical trials and is not available as a medicine.

learn KY19382

How does KY19382 actually stimulate dormant hair follicles to grow again? KY19382 stimulates dormant hair follicles by reactivating the Wnt/β-catenin signaling pathway.

learn procapil

Want to stop hormonal hair loss without touching your hormone levels? Procapil could block the enzyme doing the damage. Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

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