Morphological Substantiation of Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia

December 2018 in “ International Journal of Biomedicine ”

Elena G. Pakhomova, I. O. Smirnova

platelet rich plasma androgenetic alopecia hair density hair diameter vellus hair telogen hair anagen hair hair follicles sweat glands PRP AGA

TLDR Platelet rich plasma therapy significantly improves hair growth and increases the number of hair follicles in men with androgenetic alopecia.

In 2018, Elena E. Pakhomova and Irina O. Smirnova conducted a study on 25 men aged 20 to 43 years with androgenetic alopecia (AGA), treating them with platelet rich plasma (PRP) therapy. The treatment involved 4 intradermal injections of PRP, with a 4-week interval between each procedure. The results indicated significant improvements in hair growth indicators, with hair density and average hair diameter both increasing by 12%, and the proportion of vellus and telogen hair decreasing by 17% and 16% respectively. The ratio of anagen hair to telogen hair increased by 18%. Histological examination revealed a significant increase in the number of hair follicles at the mouth level (96% increase) and at the level of sweat glands (54% increase). The study concluded that PRP therapy's positive clinical effect is due to significant morphofunctional changes in hair follicles.

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