Morphological Substantiation of Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia

In 2018, Elena E. Pakhomova and Irina O. Smirnova conducted a study on 25 men aged 20 to 43 years with androgenetic alopecia (AGA), treating them with platelet rich plasma (PRP) therapy. The treatment involved 4 intradermal injections of PRP, with a 4-week interval between each procedure. The results indicated significant improvements in hair growth indicators, with hair density and average hair diameter both increasing by 12%, and the proportion of vellus and telogen hair decreasing by 17% and 16% respectively. The ratio of anagen hair to telogen hair increased by 18%. Histological examination revealed a significant increase in the number of hair follicles at the mouth level (96% increase) and at the level of sweat glands (54% increase). The study concluded that PRP therapy's positive clinical effect is due to significant morphofunctional changes in hair follicles.