Morphological Substantiation of Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia

December 2018 in “ International Journal of Biomedicine ”

Elena G. Pakhomova, I. O. Smirnova

platelet rich plasma androgenetic alopecia hair density hair diameter vellus hair telogen hair anagen hair hair follicles sweat glands PRP AGA

TLDR Platelet rich plasma therapy significantly improves hair growth and increases the number of hair follicles in men with androgenetic alopecia.

In 2018, Elena E. Pakhomova and Irina O. Smirnova conducted a study on 25 men aged 20 to 43 years with androgenetic alopecia (AGA), treating them with platelet rich plasma (PRP) therapy. The treatment involved 4 intradermal injections of PRP, with a 4-week interval between each procedure. The results indicated significant improvements in hair growth indicators, with hair density and average hair diameter both increasing by 12%, and the proportion of vellus and telogen hair decreasing by 17% and 16% respectively. The ratio of anagen hair to telogen hair increased by 18%. Histological examination revealed a significant increase in the number of hair follicles at the mouth level (96% increase) and at the level of sweat glands (54% increase). The study concluded that PRP therapy's positive clinical effect is due to significant morphofunctional changes in hair follicles.

View this study on ijbm.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 77 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 90 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 44 upvotes 4 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community 2024 Official beginner guide for “I’m losing my hair, what can I do?”

in General 726 upvotes 3 months ago

For hair loss, start with Finasteride, Minoxidil, Ketoconazole shampoo, and Microneedling. For severe cases, consider Dutasteride, oral Minoxidil, or hair transplants.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 15 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community What else is good. Besides the big 3.

in Chat 36 upvotes 1 month ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

Similar Research

6 / 1000+ results

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations, April 2020 in “International Journal of Molecular Sciences”

PRP injections may be a safe, effective alternative for hair loss treatment compared to minoxidil and finasteride.

research Platelet-Rich Plasma for the Treatment of Androgenic Alopecia: A Systematic Review

23 citations, June 2018 in “Facial Plastic Surgery”

Platelet-Rich Plasma (PRP) is a low-risk treatment for Androgenic Alopecia (AGA) that generally improves hair count or density, but more research is needed for optimization.

research Platelet-Rich Plasma and Stem Cells for Hair Growth: A Review of the Literature

12 citations, May 2019 in “Aesthetic Surgery Journal”

Platelet-Rich Plasma and stem cell therapy can increase hair count and density, but the best method for preparation and treatment still needs to be determined.

research Platelet-Rich Plasma for Hair Loss

4 citations, August 2018 in “Facial Plastic Surgery Clinics of North America”

Platelet-Rich Plasma (PRP), a protein-rich extract from a patient's blood, shows promise in improving hair density, thickness, and quality, but the best method of use and number of treatments needed for noticeable results are still unclear.

research Androgenetic Alopecia: Causes, Treatments, and Genetic Factors

1 citations, July 2018 in “Elsevier eBooks”

Heredity and hormones cause common hair loss, and topical minoxidil is the first recommended treatment.

research The Efficacy of Platelet-Rich Plasma in Hair Restoration and Facial Aesthetics: A Systematic Review and Meta-Analysis

31 citations, January 2019 in “Journal of Cutaneous Medicine and Surgery”

Platelet-Rich Plasma (PRP) therapy can promote hair growth and improve facial aesthetics, including reducing acne scars and facial burns, and it works best with three initial monthly injections.