Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia

August 2016 in “ Journal of Dermatological Treatment ”

Iman Hamed Elmaadawi, Basma S. Mohamed, Zeinab Ibrahim, Said Abdou, Yasmina Ahmed El Attar, Amira M. Youssef, Maha M Shamloula, Atef Taha, Hala Gabr Metwally, Mohamed M El Afandy, Mohamed L. Salem

stem cell therapy alopecia areata androgenetic alopecia bone marrow mononuclear cells follicular stem cells

TLDR Stem cell therapy may help treat tough hair loss cases.

This document explores the potential of stem cell therapy as a treatment for resistant cases of alopecia areata and androgenetic alopecia. Several studies have shown that stem cell therapy using bone marrow mononuclear cells and follicular stem cells can promote hair growth and improve patient condition, with positive results seen in most patients. However, more research is needed to confirm its safety and effectiveness, and combination therapy may be necessary. Stem cell therapy has potential as a promising treatment option for resistant cases of alopecia areata and androgenetic alopecia.

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Research cited in this study

18 / 18 results

research Neonatal Derived Mesenchymal Stem Cell Mesotherapy in Androgenetic Alopecia: A Retrospective Observational Study and Review of Literature

2 citations, May 2015 in “International Journal of Scientific Reports”

Neonatal mesenchymal stem cell therapy shows promise for treating hair loss but needs more research.

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55 citations, April 2015 in “BMC medicine”

Stem Cell Educator therapy helps regrow hair and improve life quality in alopecia areata patients.

research Alopecia Areata: Medical Treatments

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Some treatments for autoimmune hair loss work, but JAK inhibitors like tofacitinib are promising for regrowth.

research Androgenetic Alopecia: An Evidence-Based Treatment Update

151 citations, May 2014 in “American Journal of Clinical Dermatology”

Effective treatments for male pattern baldness include oral finasteride and topical minoxidil, while topical minoxidil is best for female pattern baldness.

research Many Paths to Alopecia via Compromised Regeneration of Hair Follicle Stem Cells

8 citations, May 2013 in “Journal of Investigative Dermatology”

Different problems with hair stem cell renewal can lead to hair loss.

research Establishment and Molecular Characterization of Human Dermal Mesenchymal-Like Stem Cells Derived from Human Scalp Biopsy of Androgenetic Alopecia Patient

4 citations, April 2013 in “Stem cell discovery”

research Stem Cells and Alopecia: A Review of Pathogenesis

33 citations, April 2012 in “British Journal of Dermatology”

Damaged hair follicle stem cells can cause permanent hair loss, but understanding their role could lead to new treatments.

research Investigative Guidelines for Alopecia Areata

66 citations, May 2011 in “Dermatologic therapy”

Guidelines help design better trials to compare alopecia areata treatments.

research Towards Expansion of Human Hair Follicle Stem Cells In Vitro

14 citations, April 2011 in “Cell Proliferation”

Scientists can grow human hair follicle stem cells in a lab without changing their nature, which could help treat hair loss.

research Male Androgenetic Alopecia Is Due to Hair Follicle Stem Cell Inactivation

3 citations, April 2011 in “Expert Review of Dermatology”

Male hair loss is caused by inactive hair follicle stem cells.

Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations, January 2011 in “Journal of Clinical Investigation”

Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.

Involvement of the Bulge Region with Decreased Expression of Hair Follicle Stem Cell Markers in Senile Female Cases of Alopecia Areata

research Involvement of the Bulge Region with Decreased Expression of Hair Follicle Stem Cell Markers in Senile Female Cases of Alopecia Areata

20 citations, December 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Decreased CD200 in hair follicles may cause immune issues in some alopecia areata cases.

The Advantages of Hair Follicle Pluripotent Stem Cells Over Embryonic Stem Cells and Induced Pluripotent Stem Cells for Regenerative Medicine

research The Advantages of Hair Follicle Pluripotent Stem Cells Over Embryonic Stem Cells and Induced Pluripotent Stem Cells for Regenerative Medicine

33 citations, October 2010 in “Journal of Dermatological Science”

Hair follicle stem cells are a practical and ethical option for nerve repair in regenerative medicine.

research Application of Mesenchymal Stem Cells Derived from Bone Marrow and Umbilical Cord in Human Hair Multiplication

41 citations, September 2010 in “Journal of dermatological science”

Bone marrow and umbilical cord stem cells can help grow new hair.

research Five-Year Experience in the Treatment of Alopecia Areata with Diphencyprone

37 citations, September 2009 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Diphencyprone (DPC) is an effective and safe long-term treatment for alopecia areata, especially with maintenance therapy.

research Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata

286 citations, August 2007 in “Journal of Clinical Investigation”

Alopecia areata is an autoimmune disease where T cells attack hair follicles.

research Expression of Beta-Catenin, p63, and CD34 in Hair Follicles During the Course of Androgenetic Alopecia

4 citations, August 2005 in “Archives of Dermatological Research”

Higher p63 and CD34 levels found in specific scalp areas may affect hair loss progression.

research Follicular Cell Implantation: An Emerging Cell Therapy for Hair Loss

13 citations, May 2005 in “Seminars in Plastic Surgery”

Follicular Cell Implantation might become a new treatment for hair loss and could lead to advances in organ regeneration.

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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Potential treatments for hair loss, including Minoxidil, finasteride, RU58841 and various upcoming pharmaceuticals, gene editing and cloning. It is suggested that a cure, if found, would be highly profitable due to the large number of people affected by hair loss globally.

community C’est terrible - at my wits end

in Female 442 upvotes 1 year ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

community Scientists have finally found the potential ‘cure’ for baldness

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A new study that found a single chemical could potentially be responsible for hair loss, and the potential to use this discovery to stimulate hair growth. The conversation also includes various treatments such as Minoxidil, Finasteride, RU58841, microneedling, DUT, and Botox for hair loss.

community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

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Hair loss treatments like finasteride, minoxidil, ketoconazole, PRP, and microneedling helped maintain hair for 20 years. Research and try evidence-based treatments for best results.

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The document's conclusion cannot be provided because the document cannot be parsed.

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