Expression of Beta-Catenin, p63, and CD34 in Hair Follicles During the Course of Androgenetic Alopecia

    Michala Fiuraskova, Svetlana Brychtova, Zdenek Kolar, Renata Kucerova, Martina Bienová Ph.D
    Image of study
    TLDR Higher p63 and CD34 levels found in specific scalp areas may affect hair loss progression.
    This study examined the expression of beta-catenin, p63, and CD34 in hair follicles of patients with androgenetic alopecia (AGA). The study found that p63 expression was higher in occipital skin compared to frontal areas, suggesting that p63 may participate in AGA progression. Additionally, CD34 expression was more frequent in occipital hair follicles. The study did not find significant differences in beta-catenin expression between frontal and occipital scalp. The study suggests that basic molecular mechanisms that govern hair follicle development might be applicable to postnatal, cycling hair.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 148 results

      community Better Than Minoxidil? Topical Sodium Valproate

      in Research/Science  51 upvotes 1 month ago
      Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

      community Anyone used Topical Calcipotriol (cream) or VPA ( Valproic Acid)

      in Chat  8 upvotes 4 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community How true is the statement: dead follicles don't grow back?

      in Research/Science  107 upvotes 3 weeks ago
      Hair follicles usually go dormant rather than die, and treatments like finasteride, minoxidil, and hormone therapy can sometimes reactivate them, though results vary. Complete regrowth is rare, especially in long-term bald areas, but some individuals see significant improvement with these treatments.

    Related Research

    2 / 2 results