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GlossaryTumor Protein p63 (p63)

protein crucial for epithelial tissue development and maintenance

Tumor Protein p63 (often referred to as p63 or TP63) is a protein that plays a crucial role in the development and maintenance of epithelial tissues, which are the layers of cells covering surfaces and lining cavities in the body. It is involved in regulating cell proliferation, differentiation, and apoptosis (programmed cell death). Mutations in the TP63 gene can lead to various developmental disorders and have been linked to certain types of cancer.

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research Mutations In AEC Syndrome Skin Reveal A Role For p63 In Basement Membrane Adhesion, Skin Barrier Integrity And Hair Follicle Biology

33 citations, February 2012 in “British Journal of Dermatology”

Mutations in the p63 gene affect skin adhesion, barrier integrity, and hair growth.

research Mechanism of TAp73 Inhibition by ΔNp63 and Structural Basis of p63/p73 Hetero-Tetramerization

29 citations, October 2016 in “Cell death and differentiation”

ΔNp63α stops TAp73β from working in skin cancer by blocking its access to specific genes, not by directly interacting with it.

research Telomere Dysfunction Impairs Epidermal Stem Cell Specification and Differentiation by Disrupting BMP/pSmad/P63 Signaling

19 citations, September 2019 in “PLOS genetics”

Telomere damage affects skin and hair follicle stem cells by messing up important growth signals.

research Ginsenosides Rb1 and Rd Regulate Proliferation of Mature Keratinocytes Through Induction of p63 Expression in Hair Follicles

15 citations, September 2012 in “PTR. Phytotherapy research/Phytotherapy research”

Ginsenosides Rb₁ and Rd may help prevent hair loss by promoting hair cell growth.

research Interleukin 6 and STAT3 Regulate p63 Isoform Expression in Keratinocytes During Regeneration

11 citations, November 2015 in “Experimental Dermatology”

The conclusion is that the IL-6/STAT3 activation affects p63 expression in healing wounds, which may help in hair follicle regeneration.

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