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GlossaryTumor Protein p63 (p63)

protein crucial for epithelial tissue development and maintenance

Tumor Protein p63 (often referred to as p63 or TP63) is a protein that plays a crucial role in the development and maintenance of epithelial tissues, which are the layers of cells covering surfaces and lining cavities in the body. It is involved in regulating cell proliferation, differentiation, and apoptosis (programmed cell death). Mutations in the TP63 gene can lead to various developmental disorders and have been linked to certain types of cancer.

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research P63 Regulates Satb1 to Control Tissue-Specific Chromatin Remodeling During Development of the Epidermis

166 citations , September 2011 in “The Journal of Cell Biology”

p63 controls Satb1 to help skin develop properly.

research P63 Expression in Normal Skin and Common Cutaneous Carcinomas

157 citations , October 2002 in “Journal of Cutaneous Pathology”

p63 may influence skin cancer development and cell differentiation.

research Requirement of Zinc Transporter ZIP10 for Epidermal Development: Implication of the ZIP10–p63 Axis in Epithelial Homeostasis

59 citations , October 2017 in “Proceedings of the National Academy of Sciences”

ZIP10 is crucial for skin development and maintaining healthy skin.

research P63: A Crucial Player In Epithelial Stemness Regulation

54 citations , October 2023 in “Oncogene”

research Mutations In AEC Syndrome Skin Reveal A Role For p63 In Basement Membrane Adhesion, Skin Barrier Integrity And Hair Follicle Biology

33 citations , February 2012 in “British Journal of Dermatology”

Mutations in the p63 gene affect skin adhesion, barrier integrity, and hair growth.

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