Towards Expansion of Human Hair Follicle Stem Cells In Vitro

    April 2011 in “ Cell Proliferation ”
    Jungsu S. Oh, Parsa Mohebi, Daniel L. Farkas, Jian Tajbakhsh
    Image of study
    TLDR Scientists can grow human hair follicle stem cells in a lab without changing their nature, which could help treat hair loss.
    The document from April 28, 2011, presents a study on the in vitro expansion of human hair follicle stem cells (HFSCs). Researchers successfully cultured HFSCs, both commercially available and directly isolated from hair follicles, using a specially developed medium and various supports like polystyrene, laminin, and Matrigel-coated surfaces. They achieved a two-fold expansion of these cells over 4 weeks, with flow cytometry showing an increase in the proportion of CD200+ cells, which are indicative of HFSCs, from 43.3% to 78.2% after magnetic enrichment. The expanded cells maintained their phenotype, with 80% being CD200+. The study concluded that it is possible to culture and expand HFSCs without differentiation, which is promising for stem-cell therapy in treating hair loss, despite the slow proliferation rate indicating a need for a large number of follicles for therapeutic use.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  44 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community TDM-105795 phase 2 results are in!

      in Research/Science  28 upvotes 9 months ago
      TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

      community Best Microneedle Lengths To Stimulate Stem Cells

      in Microneedling  18 upvotes 1 year ago
      Microneedling with needle lengths of 1.5mm to 2.5mm to stimulate hair follicle stem cells for potential hair growth. Using needles longer than 2.5mm is not recommended due to risk of puncturing veins in the scalp. A dermastamp is suggested over a roller.

      community Fun thought experiment about halting hair loss permamently

      in Research/Science  58 upvotes 6 months ago
      A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

      community Is there any new drug that looks promising ?

      in Research/Science  25 upvotes 8 months ago
      The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

    Related Research

    1 / 1 results