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Glossary Matrigel

gelatinous protein mixture used to simulate cellular environments

Matrigel is a gelatinous protein mixture derived from mouse tumor cells, commonly used in biological research to simulate the environment around cells. It provides a scaffold that supports cell growth and differentiation, making it particularly useful for studying cell behavior, tissue engineering, and drug testing.

Research

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research Controllable Production of Transplantable Adult Human High-Passage Dermal Papilla Spheroids Using 3D Matrigel Culture

46 citations , September 2014 in “Tissue engineering. Part A”

This study found that a 3D Matrigel culture technique for dermal papilla cell spheroids can enhance hair follicle inductivity and induce hair-like fiber differentiation in vitro, even with high-passage cells.

research Matrigel uses in cell biology and for the identification of thymosin β4, a mediator of tissue regeneration

15 citations , September 2018 in “Applied Biological Chemistry”

This review discusses the development of Matrigel and its role in identifying thymosin beta 4 as a regenerative protein, without reporting new experimental findings.

research Activating the healing process: three-dimensional culture of stem cells in Matrigel for tissue repair

5 citations , May 2024 in “BMC Biotechnology”

This study found that using three-dimensional cell culture with Matrigel enhances the biological function and stemness of stem cells, leading to improved soft tissue repair and healing by activating the host microenvironment and autologous stem cells.

research Self-assembled complete hair follicle organoids by coculture of neonatal mouse epidermal cells and dermal cells in Matrigel

4 citations , July 2022 in “Annals of translational medicine”

This study successfully developed 3D hair follicle organoids from neonatal mouse epidermal and dermal cells, showing structural and molecular resemblance to native anagen hair follicles.

research Matricellular Proteins in the Homeostasis, Regeneration, and Aging of Skin

2 citations , September 2023 in “International journal of molecular sciences”

This review summarizes the roles of matricellular proteins in skin stem cell niches, highlighting their contribution to stem cell fate, self-renewal, and potential implications for wound healing and aging.

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