Neural Potential of a Stem Cell Population in the Hair Follicle

    September 2007 in “ Cell Cycle ”
    John Mignone, José L. Roig-López, Natalia Fedtsova, Dustin E. Schones, Louis N. Manganas, Mirjana Maletić‐Savatić, William M. Keyes, Alea A. Mills, Anatoli S. Gleiberman, Michael Q. Zhang, Grigori Enikolopov
    TLDR Stem cells in hair follicles can become various cell types, including neurons.
    The study investigated the neural potential of stem cells in the bulge region of hair follicles using nestin-GFP mice. These cells demonstrated multipotency, capable of differentiating into various cell types, including neuronal, astrocytic, and oligodendrocytic cells, both in vitro and in vivo. Transcriptional profiling revealed a unique gene expression signature, indicating a distinct population of multipotent stem cells with broad differentiation potential. The research showed that these cells could form "hairspheres" and differentiate into neurons, astrocytes, smooth muscle-like cells, and keratinocytes under specific conditions. In vivo experiments confirmed their neural potential by successful differentiation into neuronal cells upon transplantation into chick embryos. The findings highlighted the plasticity of adult tissue-specific stem cells, challenging previous notions about their limited differentiation capabilities and suggesting their potential to contribute to both ectodermal and mesodermal lineages.
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