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Glossary Stem Cell Plasticity

ability of stem cells to become different cell types

Stem cell plasticity, also known as stem cell flexibility or adaptability, refers to the ability of stem cells to differentiate into a variety of cell types beyond their original lineage. For example, a stem cell from the bone marrow, which typically produces blood cells, might be able to transform into a nerve cell or a muscle cell under certain conditions. This characteristic is crucial for regenerative medicine and therapies aimed at repairing damaged tissues or treating diseases like alopecia, where hair follicle stem cells might be harnessed to regenerate hair.

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Research

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research Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer

124 citations , February 2018 in “Nature Reviews Genetics”

This review covers recent findings on stem cell plasticity under normal and cancerous conditions but presents no new experimental results, highlighting implications for regenerative medicine and cancer treatments.

research Stem cell plasticity enables hair regeneration following Lgr5+ cell loss

56 citations , May 2017 in “Nature Cell Biology”

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

research Stem cell dynamics, migration and plasticity during wound healing

211 citations , November 2018 in “Nature Cell Biology”

This article discusses the coordinated roles of different epidermal stem cells and other cell types in the skin's wound healing process and reports no new experimental results.

research Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging

7 citations , May 2022 in “Frontiers in Cell and Developmental Biology”

This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.

research Concise Review: The Plasticity of Stem Cell Niches: A General Property Behind Tissue Homeostasis and Repair

50 citations , December 2013 in “Stem Cells”

This review discusses the enhanced understanding of how stem cell niches respond adaptively to systemic signals, aging, and local perturbations, but reports no new research findings.

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Community Join

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community Hair loss research focused on chemistry for decades because we misunderstood the mechanics of growth.

51 upvotes 7 months ago

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

community What do you think about this? he says one of the causes of pattern hair loss is scars and it can be fixed

3 months ago

The conversation discusses hair loss treatments, focusing on insulin resistance, microneedling with topical melatonin, and stress reduction. Users express skepticism about the advice, preferring proven treatments like minoxidil and finasteride, while some mention alternative methods like dermal incisions and verteporfin for reducing fibrosis.

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Learn

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learn Stem Cell Factor

What is stem cell factor and why is it used in hair growth treatments? Stem cell factor promotes hair growth by signaling cell survival and division.
How does stem cell factor help activate dormant hair follicles? Stem cell factor activates dormant hair follicles by signaling through the c-Kit receptor.
Are stem cell factor products safe for long-term scalp use? Stem cell factor products lack proven long-term safety for scalp use.
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learn Apple stem cell

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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