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    Glossary Stem Cell Plasticity

    ability of stem cells to become different cell types

    Stem cell plasticity, also known as stem cell flexibility or adaptability, refers to the ability of stem cells to differentiate into a variety of cell types beyond their original lineage. For example, a stem cell from the bone marrow, which typically produces blood cells, might be able to transform into a nerve cell or a muscle cell under certain conditions. This characteristic is crucial for regenerative medicine and therapies aimed at repairing damaged tissues or treating diseases like alopecia, where hair follicle stem cells might be harnessed to regenerate hair.

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    1. Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer Nature Reviews Genetics · 2018 · 124 citations
    2. Stem cell plasticity enables hair regeneration following Lgr5+ cell loss Nature Cell Biology · 2017 · 56 citations
    3. Stem cell dynamics, migration and plasticity during wound healing Nature Cell Biology · 2018 · 211 citations
    4. Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging Frontiers in Cell and Developmental Biology · 2022 · 7 citations
    5. Concise Review: The Plasticity of Stem Cell Niches: A General Property Behind Tissue Homeostasis and Repair Stem Cells · 2013 · 50 citations
    6. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015 · 129 citations
    7. Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult mouse hair follicle stem cells Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model · 2017 · 3 citations
    8. Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice Nature · 2015 · 321 citations
    9. Nanoscale microenvironment engineering for expanding human hair follicle stem cell and revealing their plasticity Journal of Nanobiotechnology · 2021 · 15 citations
    10. Vitamin A resolves lineage plasticity to orchestrate stem cell lineage choices Science · 2024 · 1 citations
    11. Hair follicle stem cell cultures reveal self‐organizing plasticity of stem cells and their progeny The EMBO Journal · 2016 · 61 citations
    12. Understanding The Molecular Mechanisms Of Hair Follicle Stem Cell Quiescence And Genome Plasticity eCommons (Cornell University) · 2013
    13. Signaling in the stem cell niche: regulating cell fate, function and plasticity Development · 2018 · 139 citations
    14. Neural Potential of a Stem Cell Population in the Hair Follicle Cell Cycle · 2007 · 80 citations
    15. Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro‐collagen lipopeptide, creatine, and urea on skin aging signs Journal of Cosmetic Dermatology · 2015 · 36 citations
    16. Stem Cell‐Based Therapies for Skin Rejuvenation: A Systematic Review of Clinical Efficacy, Safety, and Underlying Mechanisms Journal of Cosmetic Dermatology · 2026
    17. 23 Efficacy of combined treatment with adipose tissue stem cell exosomes (ASCE) and microneedling for facial skin aging: a 12-week prospective, randomized, split-face study 2023
    18. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing Cell Reports · 2018 · 209 citations
    19. Switching roles: the functional plasticity of adult tissue stem cells The EMBO Journal · 2015 · 87 citations
    20. The in vitro plasticity of hair follicle dermal and mesenchymal stem cells Durham e-Theses (Durham University) · 2008
    21. Lineage potential, plasticity and environmental reprogramming of epithelial stem/progenitor cells Biochemical Society Transactions · 2014 · 4 citations
    22. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011 · 396 citations
    23. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells Nature · 2010 · 116 citations
    24. Skin Cell Heterogeneity in Development, Wound Healing, and Cancer Trends in cell biology · 2018 · 211 citations
    25. Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis Stem cell reviews and reports · 2022 · 7 citations
    26. Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation Frontiers in Cell and Developmental Biology · 2020 · 18 citations
    27. From neural crest cells to melanocytes: cellular plasticity during development and beyond Cellular and Molecular Life Sciences · 2019 · 66 citations
    28. Small Intestinal Organoid-Derived SP Cells Contribute to Repair of Irradiation-Induced Skin Injury Stem Cells and Development · 2005 · 11 citations
    29. Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury bioRxiv (Cold Spring Harbor Laboratory) · 2023 · 2 citations
    30. Diverse mechanisms for endogenous regeneration and repair in mammalian organs Nature · 2018 · 172 citations