Vitamin A Resolves Lineage Plasticity to Orchestrate Stem Cell Lineage Choices

    March 2024 in “ Science ”
    Matthew Tierney, Lisa Polak, Yuekui Yang, Merve Deniz Abdusselamoglu, Inwha Baek, Katherine Stewart, Elaine Fuchs
    Image of study
    TLDR Vitamin A helps skin stem cells decide their function, aiding in hair growth and wound repair.
    The study by Tierney et al. reveals that vitamin A, through its metabolite all-trans retinoic acid (atRA), plays a crucial role in regulating lineage plasticity in mouse hair follicle stem cells (HFSCs). Vitamin A restricts lineage plasticity, which must be suppressed to allow stem cells to switch fates during wound healing. By manipulating retinoid availability, the researchers were able to direct stem cells to either heal wounds or generate hair. This finding has significant implications for regenerative medicine, wound repair, and cancer treatment, as it highlights the importance of atRA in balancing stem cell contributions to different tissue types during homeostasis and repair.
    Discuss this study in the Community →

    Research cited in this study

    18 / 18 results

    Related Community Posts Join

    6 / 1000+ results

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  738 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Hair loss treatments rated (by gpt-4)

      in Research/Science  249 upvotes 2 years ago
      Rating treatments for hair loss, with the help of GPT-4, according to efficacy, evidence and tolerability; a combination of chemicals from research papers, custom compounds, and some suggestions from other users were included.

      community I don’t know what to do at this point

      in Female  88 upvotes 1 month ago
      A 21-year-old woman with female pattern baldness has tried minoxidil, red light therapy, and supplements without success. She is considering spironolactone and seeking medical advice.

      community My mum is mad annoying about Fin.

      in Chat  245 upvotes 11 months ago
      A 25-year-old man discusses his struggles with his mother's opposition to his use of Finasteride for hair loss treatment, despite it improving his condition and self-control after a hair transplant. He expresses frustration over her blaming the medication for various issues and the stress caused by her insistence to stop taking it.

    Related Research

    1 / 1 results