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Glossary Retinoids

compounds derived from vitamin A used in skincare and medicine

Retinoids are a class of compounds derived from vitamin A that are commonly used in skincare and medical treatments. They play a crucial role in regulating cell growth, differentiation, and apoptosis, making them effective for treating conditions like acne, psoriasis, and certain types of alopecia. Retinoids can also help reduce wrinkles and improve skin texture by promoting collagen production.

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learn retinol

Can retinol help enhance the absorption of ingredients like minoxidil or peptides? Retinol may enhance absorption of minoxidil and peptides by modifying skin barrier properties.
How often should retinol scalp treatments be used to see improvement without over-exfoliating? Use retinol scalp treatments 1-2 times a week to avoid over-exfoliation.
How does retinol improve scalp health and prepare the skin for other hair growth treatments? Retinol improves scalp health by promoting cellular turnover and reducing congestion.
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learn retinoic acid

learn Retinyl Palmitate

learn AC Retinol Liposome

learn Tretinoin

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

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Research

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research Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse

232 citations , January 2002 in “Mechanisms of development”

This study reports that the differential expression patterns of three retinaldehyde dehydrogenases suggest a regulated need for retinoic acid synthesis in various organs during late mouse organogenesis.

research Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled

127 citations , July 2002 in “EMBO journal”

This study found that RXRα/RARγ heterodimers are necessary for retinoic acid-induced keratinocyte proliferation in the skin, while normal epidermal maintenance does not require RAR-mediated signaling.

research Oral retinoids-present status

108 citations , November 1980 in “British Journal of Dermatology”

This article reviews the current status of oral retinoids in dermatology and reports no new clinical findings.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression (Catagen) by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

92 citations , June 2005 in “Journal of Investigative Dermatology”

This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.

research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

91 citations , November 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that DGAT1 functions as a key enzyme in murine skin to regulate retinoic acid levels and prevent retinoid toxicity, impacting hair cycle and sensitivity to retinol.

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community Minoxidil works only with Retinoic acid

314 upvotes 1 year ago

Minoxidil is more effective when combined with retinoic acid, such as tretinoin or tazarotene, enhancing hair growth. Some users experience significant regrowth, while others see minimal effects or side effects.

community New Preprint: Retinoic Acid Supports Verteporfin-Induced Regeneration

17 upvotes 2 months ago

Verteporfin followed by retinoic acid improves wound regeneration in mini-pigs. Retinoic acid does not significantly enhance regeneration in rabbits.

community Oral minoxidil vs Topical Minoxidil w/ Retinoic acid

6 upvotes 1 year ago

Topical minoxidil with retinoic acid is effective but causes scalp irritation, leading the user to consider switching to 2.5mg oral minoxidil. Oral minoxidil may cause body hair growth and heart-related side effects, so it's advised to use it under medical guidance.

community How important are Retinoic and Hydrocortisone in topical serum?

5 upvotes 1 year ago

The conversation is about using a topical serum for hair loss with ingredients like finasteride and minoxidil, and the option to exclude retinoic acid and hydrocortisone due to concerns about long-term effects. One user prefers using only finasteride, avoiding minoxidil and retinoic acid, and plans to remove hydrocortisone in future orders.

community Do the more newer gen topical retinoids e.g. tazarotene outperform tretinoin in inducing follicular sulfotransferase activity?

6 upvotes 1 month ago

Tazarotene may outperform tretinoin for hairline treatment with minoxidil, but lacks evidence. Tretinoin is recommended for the scalp, while tazarotene can be used on the face.

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