Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices

    April 2017 in “ Cell ”
    Hanseul Yang, René Adam, Yejing Ge … Elaine Fuchs
    Studysummary This study found that micro-niches within hair follicles create heterogeneity among stem cells and transit-amplifying cells, leading to specialized progenitors that control tissue morphogenesis and regeneration.
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    Research cited in this study 8

    1. Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice Nature · 2015
    2. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    3. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    4. Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop Genes & Development · 2012
    5. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    6. Genome-Wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011
    7. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
    8. Sgk3 Links Growth Factor Signaling to Maintenance of Progenitor Cells in the Hair Follicle The Journal of Cell Biology · 2005