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GlossaryTransit Amplifying Cells

cells derived from stem cells that rapidly divide before specializing

Transit Amplifying Cells (TACs) are a type of progenitor cell that arise from stem cells and undergo a limited number of rapid divisions before differentiating into specialized cells. In the context of hair biology, TACs play a crucial role in the hair growth cycle by proliferating to produce the cells that form the hair shaft and surrounding structures.

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research Local Circadian Clock Gates Cell Cycle Progression of Transient Amplifying Cells During Regenerative Hair Cycling

116 citations, May 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

research The Role of the PI3K Pathway in Maintaining Pluripotency in Mouse and Human Embryonic Stem Cells

15 citations, February 2009 in “Cell Stem Cell”

The document concludes that certain chemicals can help maintain stem cell pluripotency and that understanding cell states is crucial for tissue regeneration.

research Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices

214 citations, April 2017 in “Cell”

Different small areas within hair follicles send specific signals that control what type of cells stem cells become.

research Comparative Gene Expression Profiling of Senescent and Androgenetic Alopecia Using Microarray Analysis

6 citations, January 2010 in “Springer eBooks”

SA linked to mitochondrial issues and oxidative stress, while AGA involves disrupted hair growth genes.

research The Role of MEK and Antizyme in Keratinocyte Stem Cell Expansion and Differentiation

1 citations, April 2012 in “Cancer Research”

Antizyme reduces tumor growth and normalizes skin cell development affected by MEK.

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community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community Effect of dutasteride 0.5 mg/d in men who don't respond to finasteride (study)

in Research/Science 30 upvotes 6 days ago

Dutasteride improved hair density and thickness in men who didn't respond to finasteride, with some experiencing transient sexual dysfunction. Users discussed switching from finasteride to dutasteride, noting initial shedding but eventual hair improvement.

community Roughly 4 months on the fin/min/microneedling combo.

in Progress Pictures 182 upvotes 1 year ago

A hair loss regime consisting of finasteride, minoxidil and microneedling that was started 4 months ago with minimal side effects reported. The user also uses Nizoral once a week.

community Fluridi + minoxidil (no finasteride?)

in Treatment 5 upvotes 9 months ago

The user is using minoxidil and recently started fluridil for mild hair loss and is questioning if this treatment is sufficient without finasteride. They have finasteride available but prefer not to use it.

community Update: 16 months deep - big 3

in Progress Pictures 407 upvotes 1 year ago

The user has seen positive results after 16 months of using topical Finasteride/Minoxidil, microneedling weekly, and Tretinoin for hair loss. There are no reported side effects, and the user advises that the effectiveness of microneedling depends on the pressure applied.

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