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    Glossary Transit Amplifying Cells

    cells derived from stem cells that rapidly divide before specializing

    Transit Amplifying Cells (TACs) are a type of progenitor cell that arise from stem cells and undergo a limited number of rapid divisions before differentiating into specialized cells. In the context of hair biology, TACs play a crucial role in the hair growth cycle by proliferating to produce the cells that form the hair shaft and surrounding structures.

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    1. Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell · 2007 · 153 citations
    2. Emerging roles of transit‐amplifying cells in tissue regeneration and cancer Wiley Interdisciplinary Reviews-Developmental Biology · 2017 · 32 citations
    3. 1503 Prostaglandin E2 prevents radiotherapy-induced alopecia by attenuating transit amplifying cell apoptosis through promoting G1 arrest 2023
    4. Prostaglandin E2 prevents radiotherapy-induced alopecia by attenuating transit amplifying cell apoptosis through promoting G1 arrest bioRxiv (Cold Spring Harbor Laboratory) · 2022
    5. In Vitro Differences Between Keratinocyte Stem Cells and Transit-Amplifying Cells of the Human Hair Follicle Journal of Investigative Dermatology · 2005 · 52 citations
    6. Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    7. Data from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    8. Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    9. Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Cancer Research · 2017 · 38 citations
    10. Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog Genes & Development · 2016 · 75 citations
    11. Hair Follicle Transit-Amplifying Cells Phagocytose Dead Cells after Radiotherapeutic and Chemotherapeutic Injuries for Timely Regeneration Journal of Investigative Dermatology · 2023 · 3 citations
    12. Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling Proceedings of the National Academy of Sciences of the United States of America · 2013 · 116 citations
    13. The Potential Reversible Transition between Stem Cells and Transient-Amplifying Cells: The Limbal Epithelial Stem Cell Perspective Cells · 2024 · 1 citations
    14. Supplementary Figures, Tables and Legends from Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy 2023
    15. 701 Signaling networks between stem cell precursors, transit amplifying progenitors, and their niche in developing hair follicles Journal of Investigative Dermatology · 2016
    16. 560 Isolation of an “early” transit amplifying keratinocyte population in interfollicular human epidermis: a role for CD271 receptor Journal of Investigative Dermatology · 2022
    17. Location and phenotype of human adult keratinocyte stem cells of the skin Differentiation · 2004 · 233 citations
    18. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices Cell · 2017 · 214 citations
    19. Transdifferentiation of corneal epithelium: evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis. The International Journal of Developmental Biology · 2004 · 55 citations
    20. The River of Stem Cells Cell Stem Cell · 2009 · 15 citations
    21. Abstract 5219: The role of MEK and Antizyme in keratinocyte stem cell expansion and differentiation Cancer Research · 2012 · 1 citations
    22. Multi‐tasking epidermal stem cells: Beyond epidermal maintenance Development, Growth & Differentiation · 2018 · 23 citations
    23. Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells Genes & development · 2005 · 384 citations
    24. A single type of progenitor cell maintains normal epidermis Yearbook of Dermatology and Dermatologic Surgery · 2008
    25. Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle The Journal of Cell Biology · 2005 · 53 citations
    26. 331 Characterisation of interfollicular stem cells and early TA cells during the transition from infant to child skin Journal of Investigative Dermatology · 2021
    27. 572 Olfactory Receptor 2A4/7 Activation by the Fragrance, Cyclohexyl Salicylate, Promotes Human Hair Follicle Growth and Stem Cell Progeny Expansion Journal of Investigative Dermatology · 2022
    28. 732 Treatment with cyclohexyl salicylate, an olfactory receptor 2A4/7 agonist, promotes human hair follicle growth and bulge stem cell progeny expansion Journal of Investigative Dermatology · 2022
    29. Comparative Gene Expression Profiling of Senescent and Androgenetic Alopecia Using Microarray Analysis Springer eBooks · 2010 · 6 citations
    30. Genome-wide Maps of Histone Modifications Unwind In Vivo Chromatin States of the Hair Follicle Lineage Cell stem cell · 2011 · 191 citations