Plasticity of Epithelial Stem Cells in Tissue Regeneration

June 2014 in “ Science ”

Cédric Blanpain, Elaine Fuchs

epithelial stem cells tissue regeneration signaling pathways hair loss alopecia hair follicles regenerative medicine multilineage differentiation

TLDR Epithelial stem cells can adapt and help in tissue repair and regeneration.

The document discussed the plasticity of epithelial stem cells in tissue regeneration, emphasizing their ability to adapt and differentiate into various cell types necessary for repairing damaged tissues. It highlighted the importance of understanding the signaling pathways and environmental factors influencing stem cell behavior. The study provided insights into potential therapeutic applications for conditions such as hair loss and alopecia, where promoting the regeneration of hair follicles could be beneficial. It also explored the implications of stem cell plasticity for regenerative medicine and cancer, demonstrating that stem cells could reacquire long-term self-renewing capacities and multilineage differentiation potential during physiological and regenerative conditions.

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Research cited in this study

11 / 11 results

research Dedifferentiation of Committed Epithelial Cells Into Stem Cells In Vivo

551 citations, November 2013 in “Nature”

Certain mature cells in mouse lungs can turn back into stem cells to aid in tissue repair.

research Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair

265 citations, July 2012 in “Cell”

The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations, June 2012 in “Nature”

Hair regeneration needs dynamic cell behavior and mesenchyme presence for stem cell activation.

research Distinct Stem Cells Contribute to Mammary Gland Development and Maintenance

721 citations, October 2011 in “Nature”

Different types of long-lasting stem cells are responsible for the growth and upkeep of the mammary gland.

research Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells

396 citations, May 2011 in “Cell stem cell”

Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.

research Microenvironmental Reprogramming of Thymic Epithelial Cells to Skin Multipotent Stem Cells

116 citations, August 2010 in “Nature”

Scientists turned rat thymus cells into stem cells that can help repair skin and hair.

research Identification of the Cell Lineage at the Origin of Basal Cell Carcinoma

351 citations, February 2010 in “Nature Cell Biology”

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

research Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells

835 citations, October 2008 in “Nature Genetics”

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations, May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells

291 citations, October 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

949 citations, January 2001 in “Cell”

Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.

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