Dedifferentiation of Committed Epithelial Cells Into Stem Cells In Vivo

    November 2013 in “ Nature ”
    Purushothama Rao Tata, Hongmei Mou, Ana Pardo–Saganta … Jayaraj Rajagopal
    Studysummary This study found that differentiated airway epithelial cells can revert into functional stem cells in vivo, suggesting a more general role for this dedifferentiation process in tissue regeneration in higher vertebrates.
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    Research cited in this study 3

    1. Tracing the Cellular Origin of Cancer Nature Cell Biology · 2013
    2. Distinct Stem Cells Contribute to Mammary Gland Development and Maintenance Nature · 2011
    3. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000