TLDR Understanding where cancer cells come from helps create better prevention and treatment methods.
The document reviews the use of mouse genetic lineage-tracing experiments to identify the cellular origin of various solid tumors, which are analogs for human cancers. It explains that cancer is an evolutionary process where somatic mutations accumulate in cells, leading to uncontrolled proliferation, with most human cancers originating in epithelial tissues. The review provides examples of how different cancers, such as skin, brain, gut, lung, prostate, and breast cancers, can originate from specific cell types and mutations. For instance, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in skin cancer have been traced back to different epidermal cell lineages. It also discusses the role of the cellular microenvironment and cell fate in tumor initiation. The document concludes that understanding the cellular origins of cancer is vital for developing targeted prevention and treatment strategies.
265 citations,
July 2012 in “Cell” The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.
721 citations,
October 2011 in “Nature” Different types of long-lasting stem cells are responsible for the growth and upkeep of the mammary gland.
351 citations,
February 2010 in “Nature Cell Biology” Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
1039 citations,
February 2009 in “Nature Reviews Molecular Cell Biology” Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
835 citations,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
829 citations,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
176 citations,
February 2006 in “Cancer Research” 153 citations,
April 1998 in “Current Biology”
85 citations,
September 2013 in “International Journal of Molecular Sciences” Keratin 15 is not a reliable sole marker for identifying epidermal stem cells because it's found in various cell types.
5 citations,
May 2021 in “EMBO journal” Cell polarity signaling controls tissue mechanics and cell fate, with complex interactions and varying pathways across species.
6 citations,
October 2020 in “Frontiers in cell and developmental biology” WWOX deficiency in mice causes skin and fat tissue problems due to disrupted cell survival signals.
3 citations,
March 2023 in “International journal of molecular sciences” Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.
29 citations,
July 2014 in “PloS one” Meis1 is crucial for skin health and tumor development.
96 citations,
July 2014 in “Cold Spring Harbor Perspectives in Medicine” The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.
