WWOX Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin

October 2020 in “ Frontiers in cell and developmental biology ”

Ying Tsen Chou, Feng‐Jie Lai, Nan Shan Chang, Li Jin Hsu

WWOX deficiency keratinocyte proliferation keratinocyte differentiation apoptosis stem/progenitor cell pools epidermis MEK/ERK signaling pathway dermal collagen subcutaneous adipose tissue skin cells cell death skin layer fat tissue

TLDR WWOX deficiency in mice causes skin and fat tissue problems due to disrupted cell survival signals.

The study concluded that Wwox deficiency in mice led to significant disruptions in skin homeostasis, including reduced keratinocyte proliferation, increased apoptosis, delayed hair follicle development, and severe loss of subcutaneous adipose tissue, resulting in hypothermia. These abnormalities were linked to the downregulation of prosurvival MEK/ERK signaling. The findings highlighted the critical role of WWOX in maintaining epidermal and hair follicle homeostasis, essential for early postnatal development and overall skin health.

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