Loss of Epidermal Evi/Wls Results in a Phenotype Resembling Psoriasiform Dermatitis

    August 2013 in “ ˜The œJournal of experimental medicine/˜The œjournal of experimental medicine ”
    Iris Augustin, Julia Christina Gross, Daniel Baumann, Claudia Korn, Gráinne Kerr, Tamara Grigoryan, Cornelia Mauch, Walter Birchmeier, Michael Boutros
    TLDR Loss of a specific protein in skin cells causes symptoms similar to psoriasis.
    The study investigated the effects of losing epidermal Evi/Wls in mice, revealing a phenotype similar to psoriasiform dermatitis. Evi-LOF mice exhibited hair loss, impaired skin barrier function, increased keratinocyte proliferation, and significant immune cell infiltration. The loss of Evi disrupted the Wnt signaling pathway, leading to up-regulation of inflammation-associated genes and changes in T cell populations. The findings suggested that Evi/Wls is crucial for maintaining normal skin homeostasis and preventing chronic inflammatory skin conditions, providing insights into potential therapeutic targets for treating psoriasis-like skin disorders.
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