Loss of Epidermal Evi/Wls Results in a Phenotype Resembling Psoriasiform Dermatitis
TLDR Loss of a specific protein in skin cells causes symptoms similar to psoriasis.
The study investigated the effects of losing epidermal Evi/Wls in mice, revealing a phenotype similar to psoriasiform dermatitis. Evi-LOF mice exhibited hair loss, impaired skin barrier function, increased keratinocyte proliferation, and significant immune cell infiltration. The loss of Evi disrupted the Wnt signaling pathway, leading to up-regulation of inflammation-associated genes and changes in T cell populations. The findings suggested that Evi/Wls is crucial for maintaining normal skin homeostasis and preventing chronic inflammatory skin conditions, providing insights into potential therapeutic targets for treating psoriasis-like skin disorders.
