Multi-Tasking Epidermal Stem Cells: Beyond Epidermal Maintenance

    November 2018 in “ Development, Growth & Differentiation ”
    Hironobu Fujiwara, Ko Tsutsui, Ritsuko Morita
    Studysummary This review discusses the role of stem cell heterogeneity and compartmentalization within the epidermis and highlights their significance as niches for neighboring cells, without reporting new experimental results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 35

    1. Skin Cell Heterogeneity in Development, Wound Healing, and Cancer Trends in cell biology · 2018
    2. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    3. Foxc1 Reinforces Quiescence in Self-Renewing Hair Follicle Stem Cells Science · 2016
    4. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages Nature Communications · 2016
    5. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015
    6. Somatic Stem Cell Heterogeneity: Diversity in the Blood, Skin, and Intestinal Stem Cell Compartments Nature Reviews Molecular Cell Biology · 2015
    7. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    8. Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors Proceedings of the National Academy of Sciences of the United States of America · 2014
    9. The Structure and Organization of Lanceolate Mechanosensory Complexes at Mouse Hair Follicles eLife · 2014
    10. Regionalization of the Skin Seminars in cell & developmental biology · 2013
    11. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    12. Spatial Organization Within a Niche as a Determinant of Stem-Cell Fate Nature · 2013
    13. Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche Nature Reviews Molecular Cell Biology · 2013
    14. Perivascular Hair Follicle Stem Cells Associate With a Venule Annulus Journal of Investigative Dermatology · 2013
    15. Development and Homeostasis of the Skin Epidermis Cold Spring Harbor perspectives in biology · 2012
    16. Polyclonal Origin and Hair Induction Ability of Dermal Papillae in Neonatal and Adult Mouse Back Skin Developmental Biology · 2012
    17. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    18. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    19. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    20. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    21. The Basement Membrane Of Hair Follicle Stem Cells Is A Muscle Cell Niche Cell · 2011
    22. Differential Sensitivity of Epidermal Cell Subpopulations to Beta-Catenin-Induced Ectopic Hair Follicle Formation Developmental Biology · 2010
    23. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    24. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    25. Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate Development · 2008
    26. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    27. Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell · 2007
    28. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    29. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    30. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    31. Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis Development · 2003
    32. Hair Follicle Stem Cells: Insights from the 2003 Workshop ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    33. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    34. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    35. Characterization of Hair Follicle Bulge in Human Fetal Skin: The Human Fetal Bulge Is a Pool of Undifferentiated Keratinocytes Journal of Investigative Dermatology · 1995