211 citations
,
May 2018 in “Trends in cell biology” Different types of skin cells play specific roles in development, healing, and cancer.
75 citations
,
October 2016 in “Genes & Development” Cells in hair follicles help create fat cells in the skin by releasing a protein called Sonic Hedgehog.
142 citations
,
February 2016 in “Science” 
129 citations
,
May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
137 citations
,
April 2015 in “Nature Reviews Molecular Cell Biology” Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.
184 citations
,
November 2014 in “Developmental Cell” Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.
130 citations
,
March 2014 in “Proceedings of the National Academy of Sciences of the United States of America” Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.
106 citations
,
February 2014 in “eLife” Lanceolate complexes in mouse hair follicles are essential for touch and depend on specific cells for maintenance and regeneration.
26 citations
,
December 2013 in “Seminars in cell & developmental biology” Skin varies in thickness, color, and features due to complex genetic and cellular processes.
1235 citations
,
December 2013 in “Nature” 
133 citations
,
September 2013 in “Nature Reviews Molecular Cell Biology” Different types of stem cells and their environments are key to skin repair and maintenance.
51 citations
,
April 2013 in “Journal of Investigative Dermatology” The study investigated the relationship between hair follicle stem cells and their perivascular microenvironment, focusing on K15- stem cells in the upper bulge of hair follicles in mouse skin. It found that these stem cells were consistently associated with a venous vascular annulus, which persisted throughout the hair cycle and even after denervation, indicating its crucial role in maintaining the stem cell niche. The angiogenic factor Egfl6, expressed by the K15- bulge, was localized near this annulus, suggesting its role in promoting angiogenesis and endothelial cell migration. The research highlighted the importance of the perivascular niche in regulating hair follicle stem cells and proposed that this microenvironment was essential for the specification and maintenance of upper bulge stem cells, with potential implications for tissue engineering and stem cell-based therapies. The study involved normal fetal and postnatal FVB mice, with three embryos analyzed at each time point.
85 citations
,
July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
24 citations
,
April 2012 in “Developmental Biology” Dermal papillae cells, important for hair growth, come from multiple cell lines and can be formed by skin cells, regardless of their origin or hair cycle phase. These cells rarely divide, but their ability to shape tissue may contribute to their efficiency in inducing hair growth.
499 citations
,
September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
260 citations
,
June 2011 in “Cell” Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.
396 citations
,
May 2011 in “Cell stem cell” Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.
283 citations
,
February 2011 in “Cell stem cell” 294 citations
,
February 2011 in “Cell” Nephronectin helps attach muscle cells to hair follicles.
43 citations
,
April 2010 in “Developmental Biology” 
835 citations
,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
193 citations
,
May 2008 in “Development” The study demonstrated that activation of β-catenin signaling in adult mouse skin led to the formation of ectopic hair follicles, indicating that β-catenin plays a crucial role in hair follicle development. By inducing a stabilizing β-catenin mutation, researchers observed increased hair growth and the formation of new hair follicles in mutant mice compared to controls. The study used a genetic model involving Krt5-rtTA tetO-Cre Ctnnb1(Ex3)fl/+ mice treated with doxycycline, which resulted in densely packed, irregularly spaced hair follicles in an abnormal growth phase. The findings suggested that β-catenin signaling could reprogram epidermal cells to adopt a hair follicle fate, even in typically hairless regions like footpad skin.
153 citations
,
October 2007 in “Cell Stem Cell” New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.
1279 citations
,
November 2005 in “Nature Medicine” 335 citations
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March 2004 in “Development” The study demonstrated that transient activation of β-catenin signalling in adult mouse epidermis was sufficient to induce new hair follicles, as evidenced by the recruitment of resting hair follicles into the growth cycle and the formation of epithelial outgrowths expressing markers of hair follicle differentiation. This was achieved through the application of 4-hydroxytamoxifen (4OHT) to transgenic mice expressing a modified β-catenin. A single application of 4OHT was as effective as repeated doses. However, continuous activation of β-catenin was necessary to maintain hair follicle tumours, as these benign tumours regressed after the cessation of 4OHT treatment. The findings suggested that adult interfollicular epidermis and sebaceous glands could be reprogrammed, but sustained β-catenin signalling was crucial for maintaining the tumour state.
387 citations
,
November 2003 in “Journal of Investigative Dermatology” 421 citations
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September 2003 in “Development” The study investigated stem cell behavior in mouse epidermis, focusing on DNA label-retaining cells (LRC) that indicate infrequent division. LRC were found in hair follicles, sebaceous glands, and interfollicular epidermis, expressing keratin 15 and α6β4 integrin. They were not significantly depleted by hair growth cycles but could be reduced by phorbol ester treatment within 12 days. Myc activation increased epidermal proliferation without depleting LRC, while blocking β-catenin signaling with truncated Lef1 led to hair follicle transdifferentiation and LRC loss through proliferation. The study concluded that LRC sensitivity to stimuli varies, and lineage changes can occur independently of LRC cycling.
142 citations
,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Hair follicle stem cells can generate all hair cell types, skin, and sebaceous glands.
561 citations
,
April 2003 in “Journal of Investigative Dermatology” 1010 citations
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August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
96 citations
,
December 1995 in “Journal of Investigative Dermatology”
