Regeneration of Hair and Other Skin Appendages: A Microenvironment-Centric View

    June 2016 in “ Wound Repair and Regeneration ”
    Chenyu Huang, Yanan Du, Christoph S. Nabzdyk, Rei Ogawa, Tadanobu Koyama, Dennis P. Orgill, Xiaobing Fu
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    TLDR The microenvironment, especially mechanical forces, plays a crucial role in hair growth and could lead to new treatments for hair loss.
    The 2016 document outlines the significance of the microenvironment, particularly mechanical forces, in hair follicle regeneration and the behavior of skin appendages. It emphasizes the critical role of the follicular stem cell niche and mechanobiology in maintaining homeostasis and responding to stimuli, which can affect hair growth and loss. The review identifies key signaling pathways, including Wnt, BMP, FGF, Shh, and Notch, as potential therapeutic targets for hair regeneration. It also suggests that understanding how mechanical stimuli influence stem cell behavior is vital for developing regenerative therapies for conditions like androgenetic alopecia and burns. The document further discusses the possibility of dedifferentiating human cells into stem cells within specific microenvironments, the role of wound healing in hair cycling, and the mechanical properties affecting hair follicles. The study acknowledges funding from various sources and declares no conflicts of interest.
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