Regeneration of Hair and Other Skin Appendages: A Microenvironment-Centric View
June 2016
in “
Wound Repair and Regeneration
”
hair follicle regeneration skin appendages follicular stem cell niche mechanobiology Wnt signaling pathway BMP signaling pathway FGF signaling pathway Shh signaling pathway Notch signaling pathway androgenetic alopecia wound healing hair cycling mechanical properties stem cells hair growth hair loss stem cell niche mechanical forces Wnt BMP FGF Shh Notch pattern baldness healing hair cycle
TLDR The microenvironment, especially mechanical forces, plays a crucial role in hair growth and could lead to new treatments for hair loss.
The 2016 document outlines the significance of the microenvironment, particularly mechanical forces, in hair follicle regeneration and the behavior of skin appendages. It emphasizes the critical role of the follicular stem cell niche and mechanobiology in maintaining homeostasis and responding to stimuli, which can affect hair growth and loss. The review identifies key signaling pathways, including Wnt, BMP, FGF, Shh, and Notch, as potential therapeutic targets for hair regeneration. It also suggests that understanding how mechanical stimuli influence stem cell behavior is vital for developing regenerative therapies for conditions like androgenetic alopecia and burns. The document further discusses the possibility of dedifferentiating human cells into stem cells within specific microenvironments, the role of wound healing in hair cycling, and the mechanical properties affecting hair follicles. The study acknowledges funding from various sources and declares no conflicts of interest.
