Activation of the Notch Pathway in the Hair Cortex Leads to Aberrant Differentiation of the Adjacent Hair-Shaft Layers

    June 2000 in “ Development ”
    Meei‐Hua Lin, Cornelia Leimeister, Manfred Gessler, Raphael Kopan
    Studysummary This study reports that activating Notch signaling in the hair follicle cortex of transgenic mice caused abnormal differentiation of the medulla and cuticle, highlighting potential cell-cell interactions.
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    Research cited in this study 19

    1. The Catalog of Human Hair Keratins Journal of biological chemistry/˜The œJournal of biological chemistry · 1999
    2. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999
    3. Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    4. Proanthocyanidins from Grape Seeds Promote Proliferation of Mouse Hair Follicle Cells In Vitro and Convert Hair Cycle In Vivo Acta dermato-venereologica · 1998
    5. Localization of Plasminogen Activator Inhibitor Type 2 in Hair and Nail: Implications for Terminal Differentiation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    6. Mouse Notch: Expression in Hair Follicles Correlates with Cell Fate Determination ˜The œjournal of cell biology/˜The œJournal of cell biology · 1993
    7. Fibroblast Growth Factor Influences the Development and Cycling of Murine Hair Follicles Developmental Biology · 1993
    8. The Secret Life of the Hair Follicle Trends in genetics · 1992
    9. Inductive Properties of Hair Follicle Cells Annals of the New York Academy of Sciences · 1991
    10. Hair-Specific Keratins: Characterization and Expression of a Mouse Type I Keratin Gene Journal of Investigative Dermatology · 1991
    11. Differential Expression of Type I Hair Keratins Journal of Investigative Dermatology · 1990
    12. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989
    13. A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin Genes & Development · 1989
    14. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues Differentiation · 1988
    15. Cloning And Characterization Of A Mouse Type I Hair Keratin cDNA Journal of Investigative Dermatology · 1988
    16. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles Differentiation · 1988
    17. Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986
    18. The Effects of Epilation and Hormones on the Activity of Rat Hair Follicles Journal of Experimental Zoology · 1975
    19. Effects of the Pineal Gland Upon the Hair Cycles in Mice Journal of Investigative Dermatology · 1966

    Related research 5

    1. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Journal of Cell Science · 2013
    2. The Disruption of Sox21-Mediated Hair Shaft Cuticle Differentiation Causes Cyclic Alopecia in Mice Proceedings of the National Academy of Sciences · 2009
    3. Activation of the Notch Pathway in the Hair Cortex Leads to Aberrant Differentiation of the Adjacent Hair-Shaft Layers Development · 2000
    4. Overexpression of Human Keratin 16 Produces a Distinct Skin Phenotype in Transgenic Mouse Skin Biochemistry and Cell Biology · 1995
    5. A New Look Into an Old Problem: Keratins as Tools to Investigate Determination, Morphogenesis, and Differentiation in Skin Genes & Development · 1989