Localization of Plasminogen Activator Inhibitor Type 2 in Hair and Nail: Implications for Terminal Differentiation
TLDR PAI-2 helps in the maturation and protection of hair and nail cells.
The study investigated the localization of Plasminogen Activator Inhibitor Type 2 (PAI-2) in hair follicles and nails, revealing its role in terminal differentiation and protection against programmed cell death. PAI-2 was found in differentiating cells of the outer root sheath and medulla during the anagen phase, in the permanent portion of the catagen follicle, and in postmitotic cells adjacent to the club hair during telogen. In nails, PAI-2 was detected in the matrix and nail bed. The consistent presence of PAI-2 in maturing cells before terminal keratinization suggested it could serve as a differentiation marker and protect epithelial cells from premature cell death.
