Protease Activity, Localization, and Inhibition in the Human Hair Follicle

    August 2013 in “ International Journal of Cosmetic Science ”
    Ranjit Bhogal, Peter E. Mouser, Claire A. Higgins, G. A. Turner
    Studysummary This study found that a combination of Trichogen and climbazole may inhibit protease activity and increase the force required to remove human hair, suggesting potential to reduce excessive hair shedding.
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    Research cited in this study 6

    1. From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber Journal of Investigative Dermatology · 2009
    2. Exogen Involves Gradual Release of the Hair Club Fiber in the Vibrissa Follicle Model Experimental Dermatology · 2009
    3. Exogen, Shedding Phase of the Hair Growth Cycle: Characterization of a Mouse Model Journal of Investigative Dermatology · 2002
    4. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002
    5. Localization of Plasminogen Activator Inhibitor Type 2 in Hair and Nail: Implications for Terminal Differentiation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    6. Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects Journal of The American Academy of Dermatology · 1993