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    Glossary Nail Matrix

    tissue under the nail base that produces nail cells

    The nail matrix, also known as the matrix unguis or matrix of the nail, is the tissue located under the base of the nail, beneath the cuticle. It is responsible for producing the cells that become the nail plate, and its health and function are crucial for proper nail growth and formation. Damage to the nail matrix can result in permanent changes to the nail.

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    Research 10 of 1000+

    1. Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues II. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (hair follicle, nail bed and matrix, lingual papilla, thymic reticulum) Differentiation · 1988 · 187 citations
    2. Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege Journal of Investigative Dermatology · 2005 · 139 citations
    3. Induction of Hard Keratin Expression in Non-Nail-Matrical Keratinocytes by Nail-Matrical Fibroblasts through Epithelial-Mesenchymal Interactions Plastic & Reconstructive Surgery · 2003 · 25 citations
    4. Nail Matrix Pathology in Cronkhite–Canada Syndrome: The First Case Report American Journal of Dermatopathology · 2017 · 8 citations
    5. Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed British Journal of Dermatology · 2004 · 110 citations
    6. A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type Journal of Medical Genetics · 2006 · 60 citations
    7. Keratin expression in the normal nail unit: markers of regional differentiation British Journal of Dermatology · 2000 · 119 citations
    8. The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation 2010 · 68 citations
    9. Localization of Plasminogen Activator Inhibitor Type 2 (PAI-2) in Hair and Nail: Implications for Terminal Differentiation 1998 · 42 citations
    10. Colocalization of Cystatin M/E and its Target Proteases Suggests a Role in Terminal Differentiation of Human Hair Follicle and Nail 2008 · 22 citations
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    Community 1 of 6

    1. The final nail in the coffin. PP405 is confirmed JXL069. Reddit · 26 Jul 2026
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