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Glossary Nail Plate

hard, keratinous part of the nail protecting the nail bed

The nail plate, also known as the nail body, is the hard, translucent part of the nail that is composed of keratin. It sits on and protects the nail bed, and its growth originates from the nail matrix located under the cuticle. The health and appearance of the nail plate can provide insights into an individual's overall health.

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Research

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research Keratin film made of human hair as a nail plate model for studying drug permeation

68 citations , February 2011 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that keratin films made from human hair can potentially substitute for human nail plates in drug permeability studies, but they show higher sensitivity to penetration enhancers compared to bovine hooves.

research Proteomic analysis of hair shaft and nail plate.

29 citations , August 2011 in “PubMed”

This study describes how shotgun proteomics can identify over 300 proteins in hair shafts, potentially allowing for the diagnosis of diseases through noninvasive human proteome sampling.

research Changes in the nail plate of the elderly

September 1998 in “Journal of The European Academy of Dermatology and Venereology”

Old people's nails often have problems due to body changes, more diseases, and self-care difficulties, affecting their movement and hand use.

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.

research Unraveling the Molecular Mechanisms of Hair and Nail Genodermatoses

23 citations , November 2001 in “Archives of Dermatology”

This review discusses recent advances in the genetic understanding of inherited hair and nail disorders and reports no new clinical results.

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community Oral Biotin and Topical Minoxidil have a synergy effect in increasing hair growth, the study was only done in healthy subjects and it was only 14 days but it does prove that biotin can play a significant role as an adjunct treatment.

168 upvotes 1 year ago

Oral biotin combined with topical minoxidil may increase hair growth rate, though the study was limited to healthy subjects and did not measure hair density. Some users report personal benefits from biotin, such as faster nail growth and healthier hair, but concerns about acne and study quality were also mentioned.

community Four months on dutasteride/minoxidil oral

68 upvotes 1 week ago

A 44-year-old has been using a combination of oral dutasteride (0.5mg), minoxidil (2.5mg), and biotin (10mg) daily for four months, noticing hair regrowth with some concern about side effects like numbness. Another user increased their dutasteride dose from 0.5mg to 1mg, reporting significant hair growth without side effects.

community Update: Cbum's Transplant looks super good now

614 upvotes 1 year ago

Chris's hair transplant looks better, but the hairline is criticized for being too straight and unnatural. Some recommend using finasteride and minoxidil for maintenance.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

124 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

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