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Glossary Nail Changes

alterations in nail appearance or texture indicating health issues

Nail changes refer to alterations in the appearance, texture, or growth of fingernails or toenails, which can be indicative of various health conditions. These changes can include discoloration, thickening, brittleness, pitting, or separation from the nail bed, and may be associated with systemic diseases, nutritional deficiencies, infections, or trauma. For instance, yellowing of the nails might suggest a fungal infection, while pitting could be a sign of psoriasis.

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research Nail changes in alopecia areata: an update and review

45 citations , January 2018 in “International Journal of Dermatology”

This review explores nail changes associated with alopecia areata, noting their prevalence and impact on appearance and function, but reports no new clinical findings; the authors call for larger controlled trials.

research Anti-programmed cell death protein 1-induced lichenoid changes of the nail unit: Histopathologic description

12 citations , March 2021 in “JAAD Case Reports”

This study reported that immunotherapy in cancer patients can lead to skin-related immune adverse events, such as rashes, pruritus, and vitiligo, affecting a substantial proportion of patients.

research Nail Changes Associated With Thyroid Disease

3 citations , August 2022 in “Cutis”

This review reports that nail changes such as onycholysis, thin nails, and brittleness are associated with thyroid disorders, highlighting their importance in the early diagnosis of these conditions.

research Nail changes in non-infectious skin diseases: a narrative review

1 citations , November 2025 in “Journal of Korean Medical Association”

This review describes nail changes linked to various non-infectious skin diseases, highlighting how these alterations can help diagnose and manage conditions like psoriasis and lupus by noting specific and overlapping nail characteristics.

research Nail Changes in Chilblains Mimicking Lichen Planus

1 citations , January 2018 in “Journal of clinical & experimental dermatology research”

This study presented cases of severe and permanent nail changes resembling lichen planus in patients with chilblain lupus erythematosus, suggesting a unique pattern related to cold exposure rather than typical histopathology findings.

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community M30/India : Tried GHK-Cu for Hairline. Sharing results

in Progress Pictures 45 upvotes 5 months ago

A user experienced side effects from finasteride and switched to using GHK-Cu for hairline improvement, noticing some positive changes after three months. They used a 2mg daily dose via subcutaneous injections and reported increased hair density and baby hairs, though results were not dramatic.

community 2 years of treatment, hair continues to get worse

232 upvotes 1 year ago

A user is worried about hair loss despite using finasteride, oral minoxidil, and keto shampoo for two years and is considering switching to dutasteride. Responses suggest patience, lifestyle changes, or trying additional treatments like microneedling.

community Oral Biotin and Topical Minoxidil have a synergy effect in increasing hair growth, the study was only done in healthy subjects and it was only 14 days but it does prove that biotin can play a significant role as an adjunct treatment.

168 upvotes 1 year ago

Oral biotin combined with topical minoxidil may increase hair growth rate, though the study was limited to healthy subjects and did not measure hair density. Some users report personal benefits from biotin, such as faster nail growth and healthier hair, but concerns about acne and study quality were also mentioned.

community Gland treatment and Crude Oil Massage

8 years ago

Hair loss treatment involves gland treatment with iodine, liver extract, wild American ginseng, and black cohosh, along with crude oil scalp massage. The approach aims to stimulate hormones and improve blood circulation to promote hair growth.

community Update: Cbum's Transplant looks super good now

614 upvotes 1 year ago

Chris's hair transplant looks better, but the hairline is criticized for being too straight and unnatural. Some recommend using finasteride and minoxidil for maintenance.

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