research Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege
The nail matrix has a reduced immune response, protecting it from autoimmunity.
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30 / 1000+ resultsresearch Nail Matrix Pathology in Cronkhite–Canada Syndrome: The First Case Report
Inflammation may cause nail issues in Cronkhite–Canada Syndrome.
research Nail Changes in Patients with Graft-Versus-Host Disease
Patients with graft-versus-host disease often have nail changes related to the nail matrix, with severity not linked to skin condition.
research Localization of Plasminogen Activator Inhibitor Type 2 in Hair and Nail: Implications for Terminal Differentiation
PAI-2 helps in the maturation and protection of hair and nail cells.
research Colocalization of Cystatin M/E and Its Target Proteases Suggests a Role in Terminal Differentiation of Human Hair Follicle and Nail
Cystatin M/E helps in the final stages of hair and nail formation by controlling certain enzymes.
research Cultured Nail Keratinocytes Express Hard Keratins Characteristic of Nail and Hair In Vivo
Lab-grown nail cells show characteristics similar to natural nail and hair.
research Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla
Human nails and hair follicles have similar gene activity, especially in the cells that contribute to their growth and development.
research Nail Changes in Chilblains Mimicking Lichen Planus
Some nail changes in chilblains can look like lichen planus and may be severe and long-lasting.
research Topical Minoxidil for Nail Growth: A Conventional Medication with a Novel Indication
Minoxidil, a hair loss treatment, may help nails grow faster.
research Nail Lichen Planus in a Patient with Alopecia Totalis
A man with total hair loss also developed a rare nail condition, likely due to autoimmune issues.
research Inflammatory and Non-Melanocytic Tumoral Pathology of the Nail
The document concludes that understanding nail anatomy is key for diagnosing nail diseases, early signs of nail melanoma may allow for less aggressive treatment, and specific genetic mutations are important in thyroid cancer prognosis and treatment.
research Twenty Nail Onychomadesis: An Unusual Finding in Cronkhite-Canada Syndrome
A man with Cronkhite-Canada syndrome had all 20 nails detach but improved with treatment.
research Microtubule Associated Protein 2 Expression Defines the Companion Layer of the Anagen Hair Follicle and an Analogous Zone in the Nail Unit
MAP-2 is crucial for the structure of hair follicles and nails.
research FOXN1 Is Critical for Onycholemmal Terminal Differentiation in Nude (Foxn1nu) Mice
The Foxn1 gene is essential for normal nail and hair development.
research Possible Carbamazepine-Induced Reversible Onychomadesis
Carbamazepine may cause reversible nail detachment.
research Unilateral Beau's Lines Associated with a Fingertip Crushing Injury
A man's crushed thumb caused unusual horizontal nail ridges on all fingers of one hand.
research The Features of Onychomatricomas on In Vivo Reflectance Confocal Microscopy
Reflectance confocal microscopy can noninvasively diagnose onychomatricoma by showing unique features different from healthy nails or nail fungus.
research Onychomatricoma: Clinical Presentation and Management
The treatments for fungal nail infection, hair loss in men, benign nail tumor, and chemotherapy-associated nail bed inflammation are effective and safe.
research Onychomadesis Associated with Childhood Hand-Foot-Mouth Disease
Hand-foot-mouth disease may cause nail loss in children.
research Nails and Hair
Hair and nails can help diagnose diseases, with nail issues often linked to skin conditions and hair loss having various causes and treatments.
research Subungual Melanocytic Lesions: A Histopathological Review
Early subungual melanoma might be treated with less aggressive surgery because it invades the skin under the nail more slowly.
research Transglutaminase Activity Is Conserved in Stratified Epithelia and Skin Appendages of Mammals and Birds
Transglutaminase activity is important for skin and is found in both mammals and birds.
research Valproic Acid Monotherapy Induced Longitudinal Melanonychia
Valproic acid can cause dark lines on nails.
research Beau's Lines
Beau's lines and hair loss in a patient were linked to severe stress on the body.
research Can You Diagnose Hair Loss (Non-Scarring Alopecia)
Non-scarring hair loss can be diagnosed with two 4mm punch biopsies, one cut vertically and the other transversely.
research Genetics of Thyroid Lesions Updated
RET mutation is important in familial medullary thyroid carcinoma, and BRAF mutation in papillary thyroid carcinoma is linked to more aggressive cancer and higher death rates.
research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins
Hair and nail cells share similar proteins, indicating a common differentiation pathway.
research Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated with Alopecia Universalis
Tofacitinib citrate improved nail dystrophy and pain in patients with alopecia universalis without causing side effects.
research Hair and Nail Relationship: A Comparative Study
Hair and nails are similar keratin structures with different shapes and growth, affected by the same diseases and environmental factors.
research Clinico-Etiological Study of Nail Disorders at a Tertiary Care Center in Maharashtra, India
Nail disorders are often related to jobs like housework and manual labor, with cosmetic issues being the main concern, and are commonly caused by skin diseases like psoriasis.