Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle

November 1998 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Kenji Kizawa, Suguru Tsuchimoto, Keiko Hashimoto, Hideyo Uchiwa

S100A3 cysteine-rich calcium-binding protein hair follicle development anagen phase regression phase in situ hybridization immunohistochemical analysis cuticular cells cortical cells terminal differentiation calcium-dependent processes hair shaft formation hair growth phase hair regression phase hair root cells hair cortex cells hair formation

Studysummary This study found that the S100A3 gene is exclusively expressed in hair follicle cells differentiating into hair shaft components in mice, suggesting its important role in hair formation. Our plain-language summary of this paper — not a Tressless recommendation.

In this study, researchers cloned the cDNA for mouse S100A3, a cysteine-rich calcium-binding protein, and examined its gene expression during hair follicle development. The S100A3 gene was located on chromosome 3 and was specifically expressed in dorsal skin hair follicles, with mRNA levels peaking during the anagen phase and declining in the regression phase. In situ hybridization and immunohistochemical analysis revealed that S100A3 was prominently expressed and accumulated in cuticular and cortical cells undergoing terminal differentiation. The findings suggested that S100A3 played a crucial role in calcium-dependent processes essential for hair shaft formation.

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