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GlossaryCortical Cells

specialized hair cells providing strength, color, and texture

Cortical cells are specialized cells found in the cortex of the hair shaft, which is the thickest layer of the hair. These cells are responsible for providing strength, color, and texture to the hair by containing keratin and melanin. For professionals, understanding the structure and function of cortical cells is crucial for diagnosing and treating hair disorders such as alopecia.

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Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

Hair and nail cells share similar proteins, indicating a common differentiation pathway.

research Stiffness of Human Hair Correlates with the Fractions of Cortical Cell Types

4 citations , April 2019 in “Cosmetics”

Hair stiffness is higher when it has more para-like cortical cells.

research Cortical Cell Types and Intermediate Filament Arrangements Correlate with Fiber Curvature in Japanese Human Hair

62 citations , December 2008 in “Journal of structural biology”

Hair curvature in Japanese people is linked to specific cell types and filament arrangements in the hair cortex.

research Ultrastructural Localization of Hair Keratins, High Sulfur Keratin-Associated Proteins and Sulfhydryl Oxidase in Human Hair

9 citations , February 2016 in “Anatomical Science International”

Hair proteins change location and structure as hair cells mature.

research Expression Pattern of Human Hair Keratin Basic 1 (hHbl) in Hair Follicle and Pilomatricoma

8 citations , April 1997 in “Experimental Dermatology”

hHbl gene is active in hair shaft cells and some pilomatricomas.

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community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

in Research/Science 11 upvotes 11 months ago

Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

community Does someone like Prince William have such intense balding genetics that not even Dutasteride can save them?

in Chat 113 upvotes 10 months ago

Some men have strong balding genetics that treatments like Dutasteride, Minoxidil, or Finasteride may not fully address. Early intervention is believed to help, but many accept hair loss without treatment.

community Finasteride does deplete important nuero-active steroids

in Research/Science 9 upvotes 2 years ago

Finasteride can reduce neuroactive steroids, causing side effects like depression, anxiety, and sexual dysfunction. Some users experience persistent symptoms after stopping finasteride, while others use alternative treatments like topical solutions.

community 4 years of progress pics (Fin only). Hair feels way less dense and is constantly itchy. 30M.

in Progress Pictures 15 upvotes 2 years ago

User has been on Fin for 6 years and shares 4 years of progress pictures, noticing less dense and itchy hair. Replies suggest visiting a dermatologist, considering Dutasteride and Minoxidil, checking bloodwork, and evaluating lifestyle factors.

community I’ve been on dutesteride and oral minoxidil for two years now and I’ve only lost ground…

in Treatment 42 upvotes 1 year ago

A user on dutasteride and oral minoxidil for two years reports worsening hair loss and is seeking advice. Suggestions include consulting a professional for underlying causes, acknowledging that treatments don't work for everyone, and considering dosage adjustments or additional treatments.