TLDR Trichohyalin is modified by enzymes to form strong structures in hair cells.
The study on "The Fate of Trichohyalin" investigated the post-translational modifications of trichohyalin (THH) in hair follicles, focusing on its cross-linking by transglutaminase 3 (TGase 3) and the effects of peptidyl-arginine deiminase (PAD) modification. Researchers found that PAD modification increased the solubility of THH, making it a better substrate for TGase 3, which then efficiently cross-linked THH to form rigid structures essential for the structural integrity of hair follicles. Immunofluorescence studies confirmed the co-expression of TGase 3 and THH in the inner root sheath and medulla, highlighting TGase 3's primary role in this process.
253 citations,
March 1994 in “Developmental dynamics” Apoptosis is essential for human skin development and forming a functional epidermis.
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” 
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May 1991 in “The journal of investigative dermatology/Journal of investigative dermatology” Trichohyalin is also found in the outer layers of normal human skin.
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April 1986 in “The journal of cell biology/The Journal of cell biology” Trichohyalin is a protein in hair follicles that helps form hair filaments.
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November 1978 in “Biochemistry” α-type filaments in guinea pig hair follicles have unique structural features.
59 citations,
July 1972 in “Biochemistry” Transamidases help form strong crosslinks in hair proteins, crucial for hair strength.
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July 2010 in “The FEBS journal” The study found a specific peptide that helps detect TGase 3 activity in skin and hair follicles.
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August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology” TGase 3 helps build hair structure by forming strong bonds between proteins.
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June 2022 in “Frontiers in immunology” New protein changes may be involved in the immune attack on hair follicles in alopecia areata.
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March 2006 in “Journal of biological chemistry/The Journal of biological chemistry” Cystatin M/E strongly inhibits cathepsin V and cathepsin L, important for skin formation.
105 citations,
February 1996 in “Journal of biological chemistry/The Journal of biological chemistry” The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.
