Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding?

February 2009 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

S. Thibaut, Nükhet Cavusoglu, E. De Becker, F. Zerbib, Audrey Bednarczyk, Christine Schaeffer, Alain Van Dorsselaer, Bruno Bernard

Transglutaminase-3 TGase 3 hair shaft scaffolding hair cuticle hair cortex isopeptide cross-links keratins keratin-associated proteins KAPs hair shaft keratinization structural integrity mechanical strength rigidity

TLDR TGase 3 helps build hair structure by forming strong bonds between proteins.

The study investigated the role of Transglutaminase-3 (TGase 3) in human hair shaft scaffolding. TGase 3 was found to be specifically expressed in the hair cuticle and cortex, where it catalyzed isopeptide cross-links between keratins and keratin-associated proteins (KAPs). This activity was confirmed through various biochemical techniques, including gel electrophoresis, mass spectrometry, and western blotting. The findings suggested that TGase 3 played a significant role in hair shaft keratinization and structural integrity, contributing to the hair's mechanical strength and rigidity.

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