Cystatin M/E Is a High Affinity Inhibitor of Cathepsin V and Cathepsin L by a Reactive Site Distinct from the Legumain-binding Site

    March 2006 in “ Journal of biological chemistry/˜The œJournal of biological chemistry ”
    Tsing Cheng, Kiyotaka Hitomi, Ivonne M.J.J. van Vlijmen-Willems … Patrick L.J.M. Zeeuwen
    Studysummary This study found that cystatin M/E strongly inhibits human cathepsin V and cathepsin L via distinct non-overlapping sites, suggesting an important role in human epidermal differentiation and hair follicle morphogenesis.
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    Research cited in this study 6

    1. The Human Cysteine Protease Cathepsin V Can Compensate for Murine Cathepsin L in Mouse Epidermis and Hair Follicles European Journal of Cell Biology · 2004
    2. Epidermal Differentiation: The Role of Proteases and Their Inhibitors European Journal of Cell Biology · 2004
    3. A Null Mutation in the Cystatin M/E Gene of Ichq Mice Causes Juvenile Lethality and Defects in Epidermal Cornification Human molecular genetics online/Human molecular genetics · 2002
    4. Impaired Hair Follicle Morphogenesis and Cycling with Abnormal Epidermal Differentiation in Nackt Mice, a Cathepsin L-Deficient Mutation American Journal Of Pathology · 2002
    5. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002
    6. The Fate of Trichohyalin Journal of biological chemistry/˜The œJournal of biological chemistry · 1997