Cell Death by Cornification

The document reviewed the process of cornification, a unique form of programmed cell death in keratinocytes essential for forming the skin barrier, hair, and nails. It highlighted the roles of various enzymes, including caspase-14, DNase1L2, and cathepsins, in the differentiation and maturation of keratinocytes. The review emphasized the anti-apoptotic and anti-necrotic mechanisms that prevent premature cell death, ensuring a resilient and interconnected barrier. Despite advances, many mechanistic aspects of keratinocyte death during cornification remained unclear, underscoring the need for further research to fully understand this complex process and its implications for skin conditions and cancer.