Cell Death by Cornification

June 2013 in “ Biochimica et biophysica acta. Molecular cell research ”

Leopold Eckhart, Saskia Lippens, Erwin Tschachler, Wim Declercq

cornification keratinocytes caspase-14 DNase1L2 cathepsins skin barrier hair nails anti-apoptotic mechanisms anti-necrotic mechanisms

Studysummary This review examines the process of cornification as a mode of programmed cell death and outlines how keratinocytes activate anti-cell death mechanisms to maintain epidermal homeostasis, but reports no new results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document reviewed the process of cornification, a unique form of programmed cell death in keratinocytes essential for forming the skin barrier, hair, and nails. It highlighted the roles of various enzymes, including caspase-14, DNase1L2, and cathepsins, in the differentiation and maturation of keratinocytes. The review emphasized the anti-apoptotic and anti-necrotic mechanisms that prevent premature cell death, ensuring a resilient and interconnected barrier. Despite advances, many mechanistic aspects of keratinocyte death during cornification remained unclear, underscoring the need for further research to fully understand this complex process and its implications for skin conditions and cancer.

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