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Glossary Nails

hard keratin structures protecting finger and toe tips

Nails are hard, protective coverings made of keratin that grow at the tips of fingers and toes. They serve to protect the sensitive tips of digits and enhance the ability to pick up small objects. In a biological context, nails are considered a part of the integumentary system, which also includes skin and hair.

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Research

5 / 1000+ results

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.

research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues II. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (hair follicle, nail bed and matrix, lingual papilla, thymic reticulum)

187 citations , May 1988 in “Differentiation”

This study found that trichocytic cytokeratins, typically found in hair, are also present in nails, filiform papillae of the tongue, and the epithelial reticulum of the thymus.

research Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege

139 citations , October 2005 in “Journal of Investigative Dermatology”

This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.

Classification and Management of Skin, Hair, Nail, and Mucosal Side Effects of Epidermal Growth Factor Receptor Inhibitors

research Classification and management of skin, hair, nail and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors

138 citations , February 2007 in “European journal of cancer”

This review discusses the classification, pathogenesis, and management of skin, hair, nail, and mucosal changes due to EGFR inhibitors, emphasizing the importance of informing patients to improve therapy compliance.

research Psoriasis treatment in difficult locations: scalp, nails, and intertriginous areas

104 citations , August 2008 in “Clinics in Dermatology”

This review discusses current treatment challenges and strategies for managing psoriasis in the scalp, nails, and intertriginous areas, emphasizing the need for effective and well-tolerated long-term options, but reports no new clinical results.

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Community Join

5 / 210 results

community The final nail in the coffin. PP405 is confirmed JXL069.

440 upvotes 1 month ago

PP405 and JXL069 are confirmed to be the same molecule, leading to disappointment due to poor hair regrowth results. Users express skepticism about the credibility of Pelage and the effectiveness of JXL069.

community Is there any good collagen to use for skin, nails, hair, and joints?

2 upvotes 1 month ago

Collagen supplements for improving skin, hair, nails, and joints. Recommendations include standard collagen peptide powder and Live Conscious collagen peptide, though some users doubt their effectiveness.

community Current regimen: Topical finasteride 0.3% Minoxidil 6% once daily. 5 months. Also just started taking Zinc 20MG daily. Saw Palmetto 450mg daily. Hair, skin & nails supplements (includes a bunch of vitamins essential for hair skin and nails) Was debating on adding oral finasteride. Thoughts?

in Finasteride/Dutasteride 6 upvotes 1 year ago

The user is using a regimen of topical finasteride 0.3% and minoxidil 6% daily, along with zinc, saw palmetto, and hair supplements, but is unsure about the results and considering adding oral finasteride. Other users share mixed experiences with similar treatments, suggesting patience or switching to oral forms.

community Unexpected Hair Growth

5 upvotes 9 years ago

A 24-year-old male experienced unexpected hair growth and improved skin and nails after adding daily vegetable juices, including carrot, spinach, celery, and beet, to his diet. He is not using any other treatments like minoxidil, finasteride, or RU58841.

community Novel Idea for hair loss treatment using ‘fertiliser’. Almost guaranteed to work.

2 upvotes 8 months ago

A user suggests using a poop-based solution for hair growth, comparing it to fertilizing nails. Others humorously respond, with one mentioning microneedling as a similar concept.

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Clinics

4 / 26 results

Learn

1 / 801 results

learn Scalp Micropigmentation

Can women get scalp micropigmentation? Yes, women can get scalp micropigmentation for hair loss or thinning.

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