Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages

The study concluded that trichohyalin-like proteins played crucial and evolutionarily conserved roles in the development of skin appendages across different species, such as hair, claws, nails, and feathers. The research identified and characterized non-mammalian S100 fused-type proteins (SFTPs) in reptiles and birds, revealing proteins like scaffoldin, which showed similarities to mammalian trichohyalin. These proteins were essential for the proper formation and structural integrity of skin-related structures, indicating their fundamental importance in skin biology. The findings highlighted the need for further research into these proteins' roles in dermatology.