TLDR Reptiles have genes similar to hair proteins, suggesting hair's genetic origins predate mammals.
The study identified genes in reptiles, specifically in chickens and the green anole lizard, that encoded proteins similar to mammalian hair keratins, suggesting that the genetic basis for hair might have predated mammals. This challenged the previous belief that hair keratins were exclusive to mammals, proposing instead that these proteins were inherited from a common ancestor of mammals and sauropsids. The research found six putative orthologues of mammalian hair keratins in the anole genome and one in chicken, indicating that the ability to form hard keratin structures may have originated from a common ancestor, necessitating a revision of the evolutionary history of hair.
70 citations
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February 2007 in “Journal of Investigative Dermatology” K39 and K40 are the last keratins expressed in hair development, completing the hair keratin catalog.
18 citations
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November 2005 in “European Journal of Cell Biology” 47 citations
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July 2005 in “European Journal of Cell Biology” Terrestrial vertebrates have balanced keratin gene clusters, unlike teleost fish.
70 citations
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December 2004 in “Differentiation” The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.
38 citations
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July 2004 in “Journal of experimental zoology. Part B, Molecular and developmental evolution” Reptilian scales, feathers, and hairs evolved from changes in skin cell interactions.
91 citations
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December 2000 in “The journal of cell biology/The Journal of cell biology” Scientists successfully created mouse hair proteins in the lab, which are stable and similar to natural hair.
100 citations
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November 1997 in “Human Genetics” A new mutation in the hHb1 keratin gene is linked to the hair disorder monilethrix.
175 citations
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August 1997 in “Nature Genetics” 53 citations
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May 1988 in “Journal of Molecular Evolution”
686 citations
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February 2002 in “Current Opinion in Cell Biology” Keratin filaments are crucial for cell structure and protection, with ongoing discoveries about their genes and functions.