In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments

    December 2000 in “ ˜The œjournal of cell biology/˜The œJournal of cell biology ”
    Wei He, David Parry, L Jones … Peter M. Steinert
    Studysummary This study reports that expressed mouse type Ia and type IIa trichocyte keratins were successfully assembled into intermediate filaments in vitro, while also suggesting that disulfide bond cross linking enhances their stability.
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    Research cited in this study 8

    1. Identification of Novel Mutations in Basic Hair Keratins hHb1 and hHb6 in Monilethrix: Implications for Protein Structure and Clinical Phenotype Journal of Investigative Dermatology · 1999
    2. The Catalog of Human Hair Keratins Journal of biological chemistry/˜The œJournal of biological chemistry · 1999
    3. A Splice Site Mutation in the Human Type I Hair Keratin Gene hHa1 Results in the Expression of a Tailless Keratin Isoform Journal of Biological Chemistry · 1997
    4. Suprabasal Change and Subsequent Formation of Disulfide-Stabilized Homo- and Hetero-Dimers of Keratins During Esophageal Epithelial Differentiation Journal of Cell Science · 1993
    5. Transient Expression of Mouse Hair Keratins in Transfected HeLa Cells: Interactions Between Hard and Soft Keratins Journal of Investigative Dermatology · 1991
    6. Cloning And Characterization Of A Mouse Type I Hair Keratin cDNA Journal of Investigative Dermatology · 1988
    7. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles Differentiation · 1988
    8. Isolation of Intermediate Filament Assemblies from Human Hair Follicles The Journal of Cell Biology · 1985

    Related research 1

    1. Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments Current Opinion in Cell Biology · 2002