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GlossaryDisulfide Bonds

strong covalent links between sulfur atoms in proteins

Disulfide bonds, also known as S-S bonds, are strong covalent bonds formed between two sulfur atoms, typically within the amino acid cysteine. These bonds play a crucial role in stabilizing the three-dimensional structure of proteins, including keratin in hair, by linking different parts of the protein chain. In hair, disulfide bonds contribute to its strength and elasticity, and their alteration can affect hair texture and resilience.

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research Bleached Hair as a Standard Template to Evaluate the Performance of Commercial Hair Repair Products

August 2024 in “Cosmetics”

K18® and Olaplex® both effectively repair bleached hair, improving its strength, smoothness, and overall health.

research Analysis of Structural Change in Keratin Fibers Resulting from Chemical Treatments Using Raman Spectroscopy

52 citations , February 2005 in “Biopolymers”

Chemical hair straightening changes hair proteins and mostly fixes broken bonds.

research Morphological Analyses in Fragility of Pili Torti with Björnstad Syndrome

4 citations , November 2016 in “The Journal of Dermatology”

Pili torti hair is fragile due to loose keratin filaments and weak disulfide bonds.

research Polyphenol–Inorganic Sulfate Complex-Enriched Straightening Shampoo for Reinforcing and Restoring Reduced Hair Integrity

February 2025 in “Biomimetics”

The shampoo straightens hair while keeping it healthy and less damaged.

research Vibrational Raman and IR Data on Brown Hair Subjected to Bleaching

3 citations , September 2021 in “Data in brief”

Bleaching hair changes its structure and weakens it, which is important for understanding hair damage and creating treatments.

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community These yellow scales will be the death of me. Anyways I’m f’ed up

in Treatment 145 upvotes 2 months ago

Managing seborrheic dermatitis using ketoconazole shampoo, Nizoral, and oils like MCT and coconut oil. The user considers shaving their head and consulting a dermatologist.

community Only Finasteride 1mg once daily for 3 years. Next chapter starts now.

in Progress Pictures 76 upvotes 1 year ago

A user shared their 3-year experience using finasteride for hair loss, reporting significant improvement and no side effects. They are now starting dutasteride and plan to update on progress in a year.

community M29 - 4 YEARS on Dutasteride - almost no progress

in Chat 6 upvotes 1 month ago

The user has been on a comprehensive hair loss treatment regimen for four years, including Dutasteride, topical and oral Minoxidil, and various other treatments, but has seen little progress and is considering a hair transplant. Despite trying multiple therapies, including PRP and exosome injections, the user is still experiencing hair thinning and is hesitant about trying peptides due to potential cancer risks.