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GlossaryCytokeratins

fibrous proteins providing structural support in epithelial cells

Cytokeratins, also known as keratin proteins or CKs, are a group of fibrous structural proteins that form the intermediate filaments in epithelial cells. They provide mechanical support and help maintain the integrity of cells and tissues. In a clinical context, cytokeratins are often used as biomarkers in the diagnosis and study of various cancers, as their expression patterns can indicate the type and origin of a tumor.

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research Cytokeratins as Markers of Follicular Differentiation

121 citations , December 2001 in “American Journal of Dermatopathology”

TB and BCC tumors show similar follicular differentiation patterns.

research Immunohistochemical Localization of Cytokeratins and Involucrin in Calcifying Epithelioma: Comparative Studies with Normal Skin

49 citations , July 2006 in “British Journal of Dermatology”

Calcifying epithelioma cells can differentiate into hair cortex and outer root sheath.

research Trichofolliculoma: Case Report with Immunohistochemical Study of Cytokeratins

18 citations , March 2003 in “British journal of dermatology/British journal of dermatology, Supplement”

Trichofolliculoma has specific cytokeratin patterns that help in its diagnosis.

research Immunostaining Study of Cytokeratins in Human Hair Follicle Development

2 citations , May 2020 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia”

The study found that specific proteins are markers of hair follicle development in human fetuses.

research Contribution of Environmental Constituents in the Genomic Disruption of Cytokeratins

1 citations , July 2021 in “IntechOpen eBooks”

Environmental factors can cause mutations in skin proteins, leading to skin disorders.

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