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Glossary Cytokeratins

fibrous proteins providing structural support in epithelial cells

Cytokeratins, also known as keratin proteins or CKs, are a group of fibrous structural proteins that form the intermediate filaments in epithelial cells. They provide mechanical support and help maintain the integrity of cells and tissues. In a clinical context, cytokeratins are often used as biomarkers in the diagnosis and study of various cancers, as their expression patterns can indicate the type and origin of a tumor.

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research Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas.

277 citations , October 1982 in “The Journal of Cell Biology”

This study found that the cytokeratin patterns in skin epithelia can distinguish between different types, with basal-cell epitheliomas showing a striking similarity to the pilosebaceous tract.

research Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles

248 citations , April 1988 in “Differentiation”

In this study, researchers observed that trichocytic and epithelial cytokeratins have distinct expression patterns within various human and bovine hair follicle cells, contributing to understanding hair follicle development and growth.

research Cytokeratins as Markers of Follicular Differentiation

121 citations , December 2001 in “American Journal of Dermatopathology”

This study found that trichoblastomas and nodular basal cell carcinomas have similar cytokeratin expression patterns, indicating differentiation towards the outer root sheath epithelium.

research Immunohistochemical localization of cytokeratins and involucrin in calcifying epithelioma: comparative studies with normal skin

49 citations , July 2006 in “British Journal of Dermatology”

This study observed that calcifying epithelioma of Malherbe is composed of tumor cells that differentiate into both hair cortex and outer root sheath, supporting its hair follicle origin.

research A Novel Type II Cytokeratin, mK6irs, is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

45 citations , March 2001 in “Journal of Investigative Dermatology”

This study identified a new cytokeratin, mK6irs, specifically expressed in the inner root sheath of mouse hair follicles, distinguishing it as a member of the type II cytokeratin family.

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