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GlossaryCytokeratins

fibrous proteins providing structural support in epithelial cells

Cytokeratins, also known as keratin proteins or CKs, are a group of fibrous structural proteins that form the intermediate filaments in epithelial cells. They provide mechanical support and help maintain the integrity of cells and tissues. In a clinical context, cytokeratins are often used as biomarkers in the diagnosis and study of various cancers, as their expression patterns can indicate the type and origin of a tumor.

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research Trichofolliculoma: Case Report with Immunohistochemical Study of Cytokeratins

18 citations, March 2003 in “British journal of dermatology/British journal of dermatology, Supplement”

Trichofolliculoma has specific cytokeratin patterns that help in its diagnosis.

research Immunostaining Study of Cytokeratins in Human Hair Follicle Development

2 citations, May 2020 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia”

The study found that specific proteins are markers of hair follicle development in human fetuses.

research Contribution of Environmental Constituents in the Genomic Disruption of Cytokeratins

1 citations, July 2021 in “IntechOpen eBooks”

Environmental factors can cause mutations in skin proteins, leading to skin disorders.

research In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments

91 citations, December 2000 in “The journal of cell biology/The Journal of cell biology”

Scientists successfully created mouse hair proteins in the lab, which are stable and similar to natural hair.

research Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures Due to Spermidine/Spermine N1-Acetyltransferase Overexpression

37 citations, February 2005 in “Journal of Investigative Dermatology”

Overexpression of SSAT causes hair loss and skin issues, but reducing putrescine can help.

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