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    Glossary Cytokeratins

    fibrous proteins providing structural support in epithelial cells

    Cytokeratins, also known as keratin proteins or CKs, are a group of fibrous structural proteins that form the intermediate filaments in epithelial cells. They provide mechanical support and help maintain the integrity of cells and tissues. In a clinical context, cytokeratins are often used as biomarkers in the diagnosis and study of various cancers, as their expression patterns can indicate the type and origin of a tumor.

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    1. Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas. The Journal of Cell Biology · 1982 · 277 citations
    2. Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles Differentiation · 1988 · 248 citations
    3. Cytokeratins as Markers of Follicular Differentiation American Journal of Dermatopathology · 2001 · 121 citations
    4. Immunohistochemical localization of cytokeratins and involucrin in calcifying epithelioma: comparative studies with normal skin British Journal of Dermatology · 2006 · 49 citations
    5. A Novel Type II Cytokeratin, mK6irs, is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath Journal of Investigative Dermatology · 2001 · 45 citations
    6. Mycobacterial 65,000 MW heat-shock protein shares a carboxy-terminal epitope with human epidermal cytokeratin 1/2. PubMed · 1992 · 31 citations
    7. Trichofolliculoma: case report with immunohistochemical study of cytokeratins 2003 · 18 citations
    8. Keratinisation status and cytokeratins of the human Meibomian gland epithelium Acta Ophthalmologica · 2009 · 5 citations
    9. Immunolocalization of cytokeratins in some freshly fixed bovine epithelia. PubMed · 1991 · 4 citations
    10. Immunostaining study of cytokeratins in human hair follicle development 2020 · 2 citations
    11. <i>De novo</i> filament formation by human hair keratins K85 and K35 follows a filament development pattern distinct from cytokeratin filament networks FEBS open bio · 2021 · 2 citations
    12. Contribution of Environmental Constituents in the Genomic Disruption of Cytokeratins IntechOpen eBooks · 2021 · 1 citations
    13. Epithelial expression of cytokeratins 15 and 19 in vitiligo Journal of Cosmetic Dermatology · 2016 · 1 citations
    14. Cytokeratin 7 and 20 InTech eBooks · 2012 · 1 citations
    15. Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells Journal of Cutaneous Pathology · 1999 · 133 citations
    16. Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma British Journal of Dermatology · 1999 · 87 citations
    17. Stem cell markers (cytokeratin 15, CD34 and nestin) in primary scarring and nonscarring alopecia British Journal of Dermatology · 2009 · 54 citations
    18. Cytokeratin expression of apocrine and eccrine poromas with special reference to its expression in cuticular cells Journal of Cutaneous Pathology · 2000 · 37 citations
    19. The Autoimmune Regulator (AIRE), Which Is Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17 ˜The œAmerican journal of pathology · 2011 · 24 citations
    20. Cytokeratin 15 expression in central, centrifugal, cicatricial alopecia: new observations in normal and diseased hair follicles Journal of Cutaneous Pathology · 2011 · 14 citations
    21. Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi-1 in basal cell carcinoma International Journal of Dermatology · 2015 · 10 citations
    22. Lack of specificity of cytokeratin-15 loss in scarring alopecias Journal of the American Academy of Dermatology · 2017 · 5 citations
    23. Establishment of dermal sheath cell line from Cashmere goat and characterizing cytokeratin 13 as its novel biomarker Biotechnology Letters · 2018 · 2 citations
    24. The Localization of Cytokeratin 19 and Vimentin in Sprague Dawley Albino Rat Skin Tissue Applied Microscopy · 2014 · 1 citations
    25. 200 The relationship between the expression of cytokeratin 5/6 and clinicopathologic factors in invasive breast carcinoma Ejc Supplements · 2010
    26. Cytokeratin 19 expression in usual cutaneous carcinomas The Chinese Journal of Burns Wounds & Surface Ulcers · 2003
    27. Decreased expression of cytokeratin 15 and tropoelastin in men with androgenetic alopecia and its relationship with increased expression of p15/p16 Archives of Medical Science · 2020
    28. Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues II. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (hair follicle, nail bed and matrix, lingual papilla, thymic reticulum) Differentiation · 1988 · 187 citations
    29. Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues Differentiation · 1988 · 124 citations
    30. A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle 1998 · 139 citations